InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: EREG

Summary

InnateDB Gene

IDBG-24370.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

EREG

Gene Name

epiregulin

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000124882

Encoded Proteins

IDBP-24372

epiregulin

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Epiregulin is a member of the epidermal growth factor family. Epiregulin can function as a ligand of EGFR (epidermal growth factor receptor), as well as a ligand of most members of the ERBB (v-erb-b2 oncogene homolog) family of tyrosine-kinase receptors. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 4:74365143-74388751

Strand

Forward strand

Band

q13.3

Transcripts

ENST00000244869	ENSP00000244869
ENST00000507603
ENST00000503689

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.

Experimentally validated
Total	2 [view]
Protein-Protein	2 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005154	epidermal growth factor receptor binding
GO:0005515	protein binding
GO:0008083	growth factor activity

Biological Process

GO:0001525	angiogenesis
GO:0001550	ovarian cumulus expansion
GO:0001556	oocyte maturation
GO:0001819	positive regulation of cytokine production
GO:0007143	female meiotic division
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007267	cell-cell signaling
GO:0008284	positive regulation of cell proliferation
GO:0008285	negative regulation of cell proliferation
GO:0008543	fibroblast growth factor receptor signaling pathway
GO:0009299	mRNA transcription
GO:0009653	anatomical structure morphogenesis
GO:0009887	organ morphogenesis
GO:0019221	cytokine-mediated signaling pathway
GO:0030216	keratinocyte differentiation
GO:0030728	ovulation
GO:0038095	Fc-epsilon receptor signaling pathway
GO:0042060	wound healing
GO:0042108	positive regulation of cytokine biosynthetic process
GO:0042327	positive regulation of phosphorylation
GO:0042700	luteinizing hormone signaling pathway
GO:0043434	response to peptide hormone
GO:0043616	keratinocyte proliferation
GO:0045087	innate immune response
GO:0045089	positive regulation of innate immune response
GO:0045410	positive regulation of interleukin-6 biosynthetic process
GO:0045740	positive regulation of DNA replication
GO:0045741	positive regulation of epidermal growth factor-activated receptor activity
GO:0045840	positive regulation of mitosis
GO:0045860	positive regulation of protein kinase activity
GO:0045892	negative regulation of transcription, DNA-templated
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048015	phosphatidylinositol-mediated signaling
GO:0048146	positive regulation of fibroblast proliferation
GO:0048160	primary follicle stage
GO:0048661	positive regulation of smooth muscle cell proliferation
GO:0050680	negative regulation of epithelial cell proliferation
GO:0051151	negative regulation of smooth muscle cell differentiation
GO:0051781	positive regulation of cell division