Version 5.4
Homo sapiens Gene: CSH2
Summary
InnateDB Gene IDBG-244682.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CSH2
Gene Name chorionic somatomammotropin hormone 2
Synonyms CS-2; CSB; hCS-B; PL
Species Homo sapiens
Ensembl Gene ENSG00000213218
Encoded Proteins
IDBP-63839
chorionic somatomammotropin hormone 2
IDBP-63841
chorionic somatomammotropin hormone 2
IDBP-244684
chorionic somatomammotropin hormone 2
IDBP-602088
chorionic somatomammotropin hormone 2
IDBP-813478
chorionic somatomammotropin hormone 2
IDBP-813480
chorionic somatomammotropin hormone 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the somatotropin/prolactin family of hormones and plays an important role in growth control. The gene is located at the growth hormone locus on chromosome 17 along with four other related genes in the same transcriptional orientation; an arrangement which is thought to have evolved by a series of gene duplications. Although the five genes share a remarkably high degree of sequence identity, they are expressed selectively in different tissues. Alternative splicing generates additional isoforms of each of the five growth hormones. This particular family member is expressed mainly in the placenta and utilizes multiple transcription initiation sites. Expression of the identical mature proteins for chorionic somatomammotropin hormones 1 and 2 is upregulated during development, while the ratio of 1 to 2 increases by term. Structural and expression differences provide avenues for developmental regulation and tissue specificity. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:63872012-63881863
Strand Reverse strand
Band q23.3
Transcripts
ENST00000345366 ENSP00000308396
ENST00000336844 ENSP00000338816
ENST00000392886 ENSP00000376623
ENST00000560142 ENSP00000453452
ENST00000559928
ENST00000558516
ENST00000613718 ENSP00000478842
ENST00000620751 ENSP00000480793
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
GO:0046872 metal ion binding
Biological Process
Cellular Component
GO:0005576 extracellular region
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
hsa04630
Jak-STAT signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_020991 NM_022644 NM_022645
HUGO
OMIM
CCDS CCDS11646 CCDS42368 CCDS42369
HPRD 06688
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca