InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: QPRT

Summary

InnateDB Gene

IDBG-24543.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

QPRT

Gene Name

quinolinate phosphoribosyltransferase

Synonyms

HEL-S-90n; QPRTase

Species

Homo sapiens

Ensembl Gene

ENSG00000103485

Encoded Proteins

IDBP-239687

quinolinate phosphoribosyltransferase

IDBP-753561

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. [provided by RefSeq, Jul 2008]
This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer\'s disease, and Huntington\'s disease. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 16:29679008-29698699

Strand

Forward strand

Band

p11.2

Transcripts

ENST00000219771
ENST00000395384	ENSP00000378782
ENST00000564967
ENST00000562473	ENSP00000455183

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004514	nicotinate-nucleotide diphosphorylase (carboxylating) activity
GO:0016763	transferase activity, transferring pentosyl groups
GO:0042803	protein homodimerization activity

Biological Process

GO:0006766	vitamin metabolic process
GO:0006767	water-soluble vitamin metabolic process
GO:0009435	NAD biosynthetic process
GO:0019363	pyridine nucleotide biosynthetic process
GO:0019674	NAD metabolic process
GO:0034213	quinolinate catabolic process
GO:0044281	small molecule metabolic process
GO:0051259	protein oligomerization