Version 5.4
Homo sapiens Gene: CGB8
Summary
InnateDB Gene IDBG-246821.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CGB8
Gene Name chorionic gonadotropin, beta polypeptide 8
Synonyms CGB3; CGB5; CGB7; CGB8; hCGB
Species Homo sapiens
Ensembl Gene ENSG00000213030
Encoded Proteins
IDBP-383060
chorionic gonadotropin, beta polypeptide 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 8 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008] This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008] This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 5 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008]
This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:49047638-49049106
Strand Reverse strand
Band q13.33
Transcripts
ENST00000448456 ENSP00000403649
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005179 hormone activity
Biological Process
GO:0006915 apoptotic process
GO:0007165 signal transduction
GO:0007267 cell-cell signaling
GO:0007292 female gamete generation
GO:0016486 peptide hormone processing
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005576 extracellular region
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_15398
Glycoprotein hormones pathway
REACT_15452
Peptide hormone biosynthesis pathway
REACT_17015
Metabolism of proteins pathway
REACT_160078
Peptide hormone metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt P01233 Q6NT52
TrEMBL J3KNZ1 K7ELM3
UniProt Splice Variant
Entrez Gene 94115
UniGene Hs.446683 Hs.659014 Hs.743279
RefSeq NM_033183
HUGO HGNC:16453
OMIM 118860 608823 608824 608825 608826 608827
CCDS CCDS12753
HPRD 12311
IMGT
EMBL AC008687 AF397576 AF397577 AF397578 AF397579 AF397580 AF397581 AK291552 BC006290 BC022796 BC030994 BC041054 BC051378 BC069367 BC069526 BC103969 BC103970 BC103971 BC106059 BC106723 BC106724 BC128603 BT006890 CH471177 J00117 K00092 K03182 K03183 K03187 K03188 K03189 M13503 M13504 M13505 X00265 X00266
GenPept AAA52005 AAA52008 AAA52009 AAA53287 AAA53288 AAA96690 AAH06290 AAH22796 AAH30994 AAH41054 AAH51378 AAH69367 AAH69526 AAI03970 AAI03971 AAI03972 AAI06060 AAI06724 AAI06725 AAI28604 AAL69704 AAL69705 AAL69706 AAL69707 AAL69708 AAL69709 AAP35536 BAF84241 CAA25068 CAA25069 EAW52434 EAW52437 EAW52438 EAW52439
RNA Seq Atlas 1082 114335 93659 94115

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

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Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca