Version 5.4
Homo sapiens Gene: CHRNA5
Summary
InnateDB Gene IDBG-24824.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CHRNA5
Gene Name cholinergic receptor, nicotinic, alpha 5 (neuronal)
Synonyms LNCR2
Species Homo sapiens
Ensembl Gene ENSG00000169684
Encoded Proteins
IDBP-24826
cholinergic receptor, nicotinic, alpha 5
IDBP-240853
cholinergic receptor, nicotinic, alpha 5
IDBP-592421
cholinergic receptor, nicotinic, alpha 5
IDBP-588281
cholinergic receptor, nicotinic, alpha 5
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a nicotinic acetylcholine receptor subunit and a member of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. These receptors are thought to be heteropentamers composed of separate but similar subunits. Defects in this gene have been linked to susceptibility to lung cancer type 2 (LNCR2).[provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 15:78565520-78595269
Strand Forward strand
Band q25.1
Transcripts
ENST00000299565 ENSP00000299565
ENST00000394802 ENSP00000378281
ENST00000559554 ENSP00000453519
ENST00000559576 ENSP00000452641
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004889 acetylcholine-activated cation-selective channel activity
GO:0005230 extracellular ligand-gated ion channel activity
GO:0015276 ligand-gated ion channel activity
GO:0015464 acetylcholine receptor activity
Biological Process
GO:0006810 transport
GO:0006811 ion transport
GO:0006812 cation transport
GO:0007165 signal transduction
GO:0007268 synaptic transmission
GO:0034220 ion transmembrane transport
GO:0035094 response to nicotine
GO:0035095 behavioral response to nicotine
Cellular Component
GO:0005886 plasma membrane
GO:0005892 acetylcholine-gated channel complex
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0030054 cell junction
GO:0045211 postsynaptic membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000035594
View Gene Order
ENSBTAG00000013657
Not yet available
Pathways
NETPATH
REACTOME
REACT_13685
Neuronal System pathway
REACT_22352
Highly calcium permeable nicotinic acetylcholine receptors pathway
REACT_22149
Postsynaptic nicotinic acetylcholine receptors pathway
REACT_22126
Activation of Nicotinic Acetylcholine Receptors pathway
REACT_22336
Presynaptic nicotinic acetylcholine receptors pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_22303
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
REACT_15461
Acetylcholine Binding And Downstream Events pathway
KEGG
hsa04080
Neuroactive ligand-receptor interaction pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 1138
UniGene Hs.1614
RefSeq NM_000745
HUGO HGNC:1959
OMIM 118505
CCDS CCDS10304
HPRD 00334
IMGT
EMBL
GenPept
RNA Seq Atlas 1138

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca