InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NLGN2

Summary

InnateDB Gene

IDBG-24850.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NLGN2

Gene Name

neuroligin 2

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000169992

Encoded Proteins

IDBP-24852

neuroligin 2

IDBP-759983

IDBP-764121

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene encodes a member of a family of neuronal cell surface proteins. Members of this family may act as splice site-specific ligands for beta-neurexins and may be involved in the formation and remodeling of central nervous system synapses. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 17:7404874-7419860

Strand

Forward strand

Band

p13.1

Transcripts

ENST00000302926	ENSP00000305288
ENST00000570940	ENSP00000461092
ENST00000572893
ENST00000575301	ENSP00000461168

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004872	receptor activity
GO:0005515	protein binding
GO:0016787	hydrolase activity
GO:0042043	neurexin family protein binding
GO:0050839	cell adhesion molecule binding

Biological Process

GO:0002087	regulation of respiratory gaseous exchange by neurological system process
GO:0007158	neuron cell-cell adhesion
GO:0007416	synapse assembly
GO:0008152	metabolic process
GO:0016337	single organismal cell-cell adhesion
GO:0019233	sensory perception of pain
GO:0032230	positive regulation of synaptic transmission, GABAergic
GO:0035418	protein localization to synapse
GO:0035641	locomotory exploration behavior
GO:0045217	cell-cell junction maintenance
GO:0050804	regulation of synaptic transmission
GO:0050808	synapse organization
GO:0050885	neuromuscular process controlling balance
GO:0051965	positive regulation of synapse assembly
GO:0051968	positive regulation of synaptic transmission, glutamatergic
GO:0072553	terminal button organization
GO:0097104	postsynaptic membrane assembly
GO:0097105	presynaptic membrane assembly
GO:0097116	gephyrin clustering
GO:0097119	postsynaptic density protein 95 clustering
GO:0097151	positive regulation of inhibitory postsynaptic membrane potential
GO:2000311	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor activity
GO:2000463	positive regulation of excitatory postsynaptic membrane potential

Cellular Component

GO:0005887	integral component of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0030054	cell junction
GO:0042734	presynaptic membrane
GO:0045202	synapse
GO:0045211	postsynaptic membrane
GO:0060077	inhibitory synapse

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000051790

View Gene Order

ENSBTAG00000020252

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04514

Cell adhesion molecules (CAMs) pathway

INOH

PID NCI

Cross-References

SwissProt

Q8NFZ4

TrEMBL

UniProt Splice Variant

Entrez Gene

57555

UniGene

Hs.26229

RefSeq

NM_020795

HUGO

HGNC:14290

OMIM

606479

CCDS

CCDS11103

HPRD

07348

IMGT

EMBL

AB037787 AF376802

GenPept

AAM46111 BAA92604

RNA Seq Atlas

57555