Version 5.4
Homo sapiens Gene: TRIM68
Summary
InnateDB Gene IDBG-25117.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol TRIM68
Gene Name tripartite motif containing 68
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000167333
Encoded Proteins
IDBP-25119
tripartite motif containing 68
IDBP-597255
tripartite motif containing 68
IDBP-602581
tripartite motif containing 68
IDBP-587645
tripartite motif containing 68
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein which contains a RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions. This gene is expressed in many cancer cell lines. Its expression in normal tissues, however, was found to be restricted to prostate. This gene was also found to be differentially expressed in androgen-dependent versus androgen-independent prostate cancer cells. [provided by RefSeq, Oct 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:4598672-4608259
Strand Reverse strand
Band p15.4
Transcripts
ENST00000300747 ENSP00000300747
ENST00000531101 ENSP00000431783
ENST00000526337 ENSP00000434681
ENST00000531717
ENST00000531644
ENST00000532108
ENST00000533021 ENSP00000436112
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 11 experimentally validated interaction(s) in this database.
Experimentally validated
Total 11 [view]
Protein-Protein 11 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004842 ubiquitin-protein transferase activity
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0016874 ligase activity
GO:0035035 histone acetyltransferase binding
GO:0046872 metal ion binding
GO:0050681 androgen receptor binding
Biological Process
GO:0051865 protein autoubiquitination
GO:0060765 regulation of androgen receptor signaling pathway
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005730 nucleolus
GO:0005737 cytoplasm
GO:0005794 Golgi apparatus
GO:0048471 perinuclear region of cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000073968
View Gene Order
ENSBTAG00000011332
Not yet available
Pathways
NETPATH
NetPath_2
AndrogenReceptor pathway
REACTOME
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.523438 Hs.738828
RefSeq NM_018073
HUGO
OMIM
CCDS CCDS31356
HPRD 11507
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca