InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Gene: Maea

Summary

InnateDB Gene

IDBG-251747.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Maea

Gene Name

macrophage erythroblast attacher

Synonyms

1110030D19Rik; EMP; Gid9

Species

Mus musculus

Ensembl Gene

ENSMUSG00000079562

Encoded Proteins

IDBP-251749

macrophage erythroblast attacher

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene does not have any Entrez summary - the following is the summary from its human ortholog ENSG00000090316:
This gene product mediates the attachment of erythroblasts to macrophages. This attachment promotes terminal maturation and enucleation of erythroblasts, presumably by suppressing apoptosis. This protein is an integral membrane protein with the N-terminus on the extracellular side and the C-terminus on the cytoplasmic side of the cell. Two immunologically related isoforms of erythroblast macrophage protein with apparent molecular weights of 33 kD and 36 kD were detected in macrophage membranes; this gene encodes the larger isoform. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]
This gene encodes a protein that mediates the attachment of erythroblasts to macrophages. This attachment promotes terminal maturation and enucleation of erythroblasts, presumably by suppressing apoptosis. The encoded protein is an integral membrane protein with the N-terminus on the extracellular side and the C-terminus on the cytoplasmic side of the cell. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 5:33335572-33373294

Strand

Forward strand

Band

Transcripts

ENSMUST00000114449

ENSMUSP00000110093

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding

Biological Process

GO:0007010	cytoskeleton organization
GO:0007049	cell cycle
GO:0007155	cell adhesion
GO:0033033	negative regulation of myeloid cell apoptotic process
GO:0043249	erythrocyte maturation
GO:0048821	erythrocyte development
GO:0048822	enucleate erythrocyte development
GO:0051301	cell division

Cellular Component

GO:0005634	nucleus
GO:0005819	spindle
GO:0005826	actomyosin contractile ring
GO:0005856	cytoskeleton
GO:0005887	integral component of plasma membrane
GO:0015629	actin cytoskeleton
GO:0016363	nuclear matrix

Orthologs

Species

Homo sapiens

Bos taurus

Gene ID

Gene Order

ENSG00000090316

View Gene Order

ENSBTAG00000012575

Not yet available

Cross-References

SwissProt

Q4VC33

TrEMBL

UniProt Splice Variant

Entrez Gene

59003

UniGene

Mm.281642

RefSeq

NM_021500 XM_006504041

OMIM

CCDS

CCDS39063

HPRD

IMGT

MGI ID

MGI:1891748

MGI Symbol

Maea

EMBL

AF263247 AK034859 AK075637 AK145800 AK152523 AK169149 BC039054 BC058687

GenPept

AAF72195 AAH39054 AAH58687 BAC28857 BAC35873 BAE26657 BAE31283 BAE40928

RNA Seq Atlas

59003