Homo sapiens Gene: MMP11 | |||||||||||||||||
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Summary | |||||||||||||||||
InnateDB Gene | IDBG-2572.6 | ||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||
Gene Symbol | MMP11 | ||||||||||||||||
Gene Name | matrix metallopeptidase 11 (stromelysin 3) | ||||||||||||||||
Synonyms | SL-3; ST3; STMY3 | ||||||||||||||||
Species | Homo sapiens | ||||||||||||||||
Ensembl Gene | ENSG00000099953 | ||||||||||||||||
Encoded Proteins |
matrix metallopeptidase 11 (stromelysin 3)
matrix metallopeptidase 11 (stromelysin 3)
matrix metallopeptidase 11 (stromelysin 3)
matrix metallopeptidase 11 (stromelysin 3)
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Protein Structure | |||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||
Entrez Gene | |||||||||||||||||
Summary |
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP's, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq, Jul 2008] Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP\'s are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is activated intracellularly by furin within the constitutive secretory pathway. Also in contrast to other MMP\'s, this enzyme cleaves alpha 1-proteinase inhibitor but weakly degrades structural proteins of the extracellular matrix. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||
Type | Protein coding | ||||||||||||||||
Genomic Location | Chromosome 22:23768226-23784316 | ||||||||||||||||
Strand | Forward strand | ||||||||||||||||
Band | q11.23 | ||||||||||||||||
Transcripts | |||||||||||||||||
Interactions | |||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||
NETPATH | |||||||||||||||||
REACTOME |
Activation of Matrix Metalloproteinases pathway
Collagen degradation pathway
Extracellular matrix organization pathway
Degradation of the extracellular matrix pathway
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KEGG | |||||||||||||||||
INOH | |||||||||||||||||
PID NCI | |||||||||||||||||
Cross-References | |||||||||||||||||
SwissProt | |||||||||||||||||
TrEMBL | F8WDI7 | ||||||||||||||||
UniProt Splice Variant | |||||||||||||||||
Entrez Gene | 4320 | ||||||||||||||||
UniGene | Hs.143751 | ||||||||||||||||
RefSeq | NM_005940 | ||||||||||||||||
HUGO | HGNC:7157 | ||||||||||||||||
OMIM | 185261 | ||||||||||||||||
CCDS | CCDS13816 | ||||||||||||||||
HPRD | 01705 | ||||||||||||||||
IMGT | |||||||||||||||||
EMBL | AP000349 | ||||||||||||||||
GenPept | |||||||||||||||||
RNA Seq Atlas | 102725056 4320 | ||||||||||||||||