Version 5.4
Homo sapiens Gene: SLX1A
Summary
InnateDB Gene IDBG-25883.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLX1A
Gene Name SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000132207
Encoded Proteins
IDBP-25885
SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae)
IDBP-25889
SLX1 structure-specific endonuclease subunit homolog A (S. cerevisiae)
IDBP-746260
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that is an important regulator of genome stability. The protein represents the catalytic subunit of the SLX1-SLX4 structure-specific endonuclease, which can resolve DNA secondary structures that are formed during repair and recombination processes. Two identical copies of this gene are located on the p arm of chromosome 16 due to a segmental duplication; this record represents the more centromeric copy. Alternative splicing results in multiple transcript variants. Read-through transcription also occurs between this gene and the downstream SULT1A3 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3) gene. [provided by RefSeq, Nov 2010] This gene encodes a protein that is an important regulator of genome stability. The protein represents the catalytic subunit of the SLX1-SLX4 structure-specific endonuclease, which can resolve DNA secondary structures that are formed during repair and recombination processes. Two identical copies of this gene are located on the p arm of chromosome 16 due to a segmental duplication; this record represents the more telomeric copy. Alternative splicing results in multiple transcript variants. Read-through transcription also occurs between this gene and the downstream SULT1A4 (sulfotransferase family, cytosolic, 1A, phenol-preferring, member 4) gene. [provided by RefSeq, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:30193887-30197561
Strand Forward strand
Band p11.2
Transcripts
ENST00000251303 ENSP00000251303
ENST00000345535 ENSP00000333945
ENST00000565081
ENST00000564268
ENST00000563995 ENSP00000455250
ENST00000563616
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008821 crossover junction endodeoxyribonuclease activity
GO:0017108 5'-flap endonuclease activity
GO:0046872 metal ion binding
Biological Process
GO:0000724 double-strand break repair via homologous recombination
GO:0000737 DNA catabolic process, endonucleolytic
GO:0006281 DNA repair
GO:0010792 DNA double-strand break processing involved in repair via single-strand annealing
Cellular Component
GO:0033557 Slx1-Slx4 complex
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene
RefSeq NM_001014999 NM_001015000 XM_006726623
HUGO
OMIM
CCDS CCDS32431 CCDS32432
HPRD 18681
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca