Version 5.4
Homo sapiens Gene: FXR2
Summary
InnateDB Gene IDBG-26108.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol FXR2
Gene Name fragile X mental retardation, autosomal homolog 2
Synonyms FMR1L2; FXR2P
Species Homo sapiens
Ensembl Gene ENSG00000129245
Encoded Proteins
IDBP-26110
fragile X mental retardation, autosomal homolog 2
IDBP-763623
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a RNA binding protein containing two KH domains and one RCG box, which is similar to FMRP and FXR1. It associates with polyribosomes, predominantly with 60S large ribosomal subunits. This encoded protein may self-associate or interact with FMRP and FXR1. It may have a role in the development of fragile X mental retardation syndrome. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:7591230-7614871
Strand Reverse strand
Band p13.1
Transcripts
ENST00000250113 ENSP00000250113
ENST00000573057
ENST00000571079
ENST00000573957
ENST00000571597 ENSP00000459230
ENST00000574490
ENST00000576693
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 103 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 103 [view]
Protein-Protein 100 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003723 RNA binding
GO:0005515 protein binding
GO:0042802 identical protein binding
GO:0044822 poly(A) RNA binding
Biological Process
Cellular Component
GO:0005737 cytoplasm
GO:0016020 membrane
GO:0022625 cytosolic large ribosomal subunit
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000018765
View Gene Order
ENSBTAG00000005462
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa03013
RNA transport pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.52788 Hs.656518
RefSeq NM_004860
HUGO
OMIM
CCDS CCDS45604
HPRD 05629
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca