Version 5.4
Mus musculus Gene: Naip2
Summary
InnateDB Gene IDBG-262522.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Naip2
Gene Name NLR family, apoptosis inhibitory protein 2
Synonyms Birc1b; Naip-rs6
Species Mus musculus
Ensembl Gene ENSMUSG00000078945
Encoded Proteins
IDBP-177195
NLR family, apoptosis inhibitory protein 2
IDBP-400784
NLR family, apoptosis inhibitory protein 2
IDBP-625253
NLR family, apoptosis inhibitory protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 21918512
Naip2 functions as a specific inflammasome receptor for the type III secretion system rod component of Salmonella and Burkholderia bacterial species.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 13:100144063-100202092
Strand Reverse strand
Band D1
Transcripts
ENSMUST00000067975 ENSMUSP00000070827
ENSMUST00000117913 ENSMUSP00000113890
ENSMUST00000167986 ENSMUSP00000125852
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
GO:0046872 metal ion binding
Biological Process
GO:0006915 apoptotic process
GO:0006954 inflammatory response
GO:0016045 detection of bacterium
GO:0042742 defense response to bacterium
GO:0045087 innate immune response (InnateDB)
GO:0070269 pyroptosis
GO:0071391 cellular response to estrogen stimulus
Cellular Component
GO:0072557 IPAF inflammasome complex
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
KEGG
mmu04621
NOD-like receptor signaling pathway pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Mm.89961
RefSeq NM_001126182 NM_010872
OMIM
CCDS CCDS26726
HPRD
IMGT
MGI ID
MGI Symbol
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca