InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: SCN11A

Summary

InnateDB Gene

IDBG-26272.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

SCN11A

Gene Name

sodium channel, voltage-gated, type XI, alpha subunit

Synonyms

FEPS3; HSAN7; NaN; NAV1.9; PN5; SCN12A; SNS-2

Species

Homo sapiens

Ensembl Gene

ENSG00000168356

Encoded Proteins

IDBP-26274

sodium channel, voltage-gated, type XI, alpha subunit

IDBP-372511

sodium channel, voltage-gated, type XI, alpha subunit

IDBP-372512

sodium channel, voltage-gated, type XI, alpha subunit

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Voltage-gated sodium channels are membrane protein complexes that play a fundamental role in the rising phase of the action potential in most excitable cells. Alpha subunits, such as SCN11A, mediate voltage-dependent gating and conductance, while auxiliary beta subunits regulate the kinetic properties of the channel and facilitate membrane localization of the complex. Aberrant expression patterns or mutations of alpha subunits underlie a number of disorders. Each alpha subunit consists of 4 domains connected by 3 intracellular loops; each domain consists of 6 transmembrane segments and intra- and extracellular linkers.[supplied by OMIM, Apr 2004]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 3:38845769-38950561

Strand

Reverse strand

Band

p22.2

Transcripts

ENST00000302328	ENSP00000307599
ENST00000456224	ENSP00000416757
ENST00000444237	ENSP00000408028

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005216	ion channel activity
GO:0005248	voltage-gated sodium channel activity
GO:0005515	protein binding

Biological Process

GO:0006811	ion transport
GO:0006814	sodium ion transport
GO:0008219	cell death
GO:0019228	neuronal action potential
GO:0034765	regulation of ion transmembrane transport
GO:0035725	sodium ion transmembrane transport
GO:0042493	response to drug
GO:0051930	regulation of sensory perception of pain
GO:0055085	transmembrane transport
GO:0086010	membrane depolarization during action potential

Cellular Component

GO:0001518	voltage-gated sodium channel complex
GO:0005886	plasma membrane
GO:0016020	membrane
GO:0030424	axon
GO:0044299	C-fiber
GO:0070062	extracellular vesicular exosome

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000034115

View Gene Order

ENSBTAG00000017174

Not yet available

Pathways

NETPATH

REACTOME

REACT_22266

Interaction between L1 and Ankyrins pathway

REACT_22205

L1CAM interactions pathway

REACT_111045

Developmental Biology pathway

REACT_18266

Axon guidance pathway

KEGG

INOH

PID NCI

Cross-References

SwissProt

Q9UI33

TrEMBL

UniProt Splice Variant

Entrez Gene

11280

UniGene

Hs.186877 Hs.591657

RefSeq

NM_001287223 NM_014139

HUGO

HGNC:10583

OMIM

604385

CCDS

CCDS33737

HPRD

IMGT

EMBL

AC116038 AF109737 AF150882 AF188679 AJ417790 AY686224

GenPept

AAF17480 AAF24976 AAF24980 AAT95434 CAD10507

RNA Seq Atlas

11280