InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: RPS17L

Summary

InnateDB Gene

IDBG-26644.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

RPS17L

Gene Name

ribosomal protein S17-like

Synonyms

DBA4; RPS17L; RPS17L1; RPS17L2; S17

Species

Homo sapiens

Ensembl Gene

ENSG00000182774

Encoded Proteins

IDBP-26646

ribosomal protein S17-like

IDBP-601895

ribosomal protein S17-like

IDBP-597130

ribosomal protein S17-like

IDBP-604022

ribosomal protein S17-like

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S17E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S17E family of ribosomal proteins and is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia 4. Alternative splicing of this gene results in multiple transcript variants. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Apr 2014]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 15:82536753-82540564

Strand

Reverse strand

Band

q25.2

Transcripts

ENST00000330244	ENSP00000346046
ENST00000560229
ENST00000561157	ENSP00000453910
ENST00000558397	ENSP00000452889
ENST00000561068	ENSP00000453894
ENST00000560612
ENST00000561440
ENST00000560639
ENST00000559776
ENST00000559273

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 88 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	88 [view]
Protein-Protein	85 [view]
Protein-DNA	3 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003735	structural constituent of ribosome
GO:0044822	poly(A) RNA binding

Biological Process

GO:0000028	ribosomal small subunit assembly
GO:0000184	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay
GO:0006364	rRNA processing
GO:0006412	translation
GO:0006413	translational initiation
GO:0006414	translational elongation
GO:0006415	translational termination
GO:0006614	SRP-dependent cotranslational protein targeting to membrane
GO:0010467	gene expression
GO:0016032	viral process
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0019058	viral life cycle
GO:0019083	viral transcription
GO:0034101	erythrocyte homeostasis
GO:0042274	ribosomal small subunit biogenesis
GO:0044267	cellular protein metabolic process

Cellular Component

GO:0005622	intracellular
GO:0005829	cytosol
GO:0005840	ribosome
GO:0016020	membrane
GO:0022627	cytosolic small ribosomal subunit
GO:0070062	extracellular vesicular exosome