Version 5.4
Homo sapiens Gene: DNAH2
Summary
InnateDB Gene IDBG-26706.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol DNAH2
Gene Name dynein, axonemal, heavy chain 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000183914
Encoded Proteins
IDBP-26714
dynein, axonemal, heavy chain 2
IDBP-759681
IDBP-761330
IDBP-760589
IDBP-764410
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Dyneins are microtubule-associated motor protein complexes composed of several heavy, light, and intermediate chains. The axonemal dyneins, found in cilia and flagella, are components of the outer and inner dynein arms attached to the peripheral microtubule doublets. DNAH2 is an axonemal inner arm dynein heavy chain (Chapelin et al., 1997 [PubMed 9256245]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:7717354-7833744
Strand Forward strand
Band p13.1
Transcripts
ENST00000389173 ENSP00000373825
ENST00000575498
ENST00000570791 ENSP00000460245
ENST00000575105 ENSP00000461726
ENST00000574518 ENSP00000461273
ENST00000572933 ENSP00000458355
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0016887 ATPase activity
Biological Process
GO:0001539 cilium or flagellum-dependent cell motility
GO:0006200 ATP catabolic process
GO:0007018 microtubule-based movement
GO:0008152 metabolic process
Cellular Component
GO:0005858 axonemal dynein complex
GO:0005874 microtubule
GO:0030286 dynein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005237
View Gene Order
ENSBTAG00000008605
Not yet available
Pathways
NETPATH
REACTOME
KEGG
hsa05016
Huntington's disease pathway
INOH
PID NCI
Cross-References
SwissProt Q9P225
TrEMBL
UniProt Splice Variant
Entrez Gene 146754
UniGene Hs.367649
RefSeq XM_005256470 NM_020877
HUGO HGNC:2948
OMIM 603333
CCDS CCDS32551
HPRD 17214
IMGT
EMBL AB040936 AC025335 AC087388 AK128517 AK292607 BC034225 U83570
GenPept AAB82760 AAH34225 BAA96027 BAF85296
RNA Seq Atlas 146754

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca