InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ICAM1

Summary

InnateDB Gene

IDBG-26804.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ICAM1

Gene Name

intercellular adhesion molecule 1

Synonyms

BB2; CD54; P3.58

Species

Homo sapiens

Ensembl Gene

ENSG00000090339

Encoded Proteins

IDBP-26806

intercellular adhesion molecule 1

IDBP-370731

intercellular adhesion molecule 1

IDBP-764302

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 10924857

ICAM1 is an inducible surface glycoprotein belonging to the immunoglobulin superfamily that is involved in a wide range of inflammatory and immune responses.

PMID 3349522

ICAM1 binds to ITGAL/ITGB2 (CD11a/CD18) and ITGAM/ITGB2 (CD11b/CD18) expressed by leukocytes and promotes their adhesion and transendothelial migration.

Entrez Gene

Summary

This gene encodes a cell surface glycoprotein which is typically expressed on endothelial cells and cells of the immune system. It binds to integrins of type CD11a / CD18, or CD11b / CD18 and is also exploited by Rhinovirus as a receptor. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:10270835-10286615

Strand

Forward strand

Band

p13.2

Transcripts

ENST00000264832	ENSP00000264832
ENST00000423829	ENSP00000413124
ENST00000585443
ENST00000588645	ENSP00000465680
ENST00000592686

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 156 experimentally validated interaction(s) in this database.

Experimentally validated
Total	156 [view]
Protein-Protein	145 [view]
Protein-DNA	11 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001618	virus receptor activity
GO:0004872	receptor activity
GO:0004888	transmembrane signaling receptor activity
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0032403	protein complex binding

Biological Process

GO:0001541	ovarian follicle development
GO:0001666	response to hypoxia
GO:0001910	regulation of leukocyte mediated cytotoxicity
GO:0001975	response to amphetamine
GO:0002291	T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell
GO:0002438	acute inflammatory response to antigenic stimulus
GO:0002457	T cell antigen processing and presentation
GO:0002693	positive regulation of cellular extravasation
GO:0007155	cell adhesion
GO:0007157	heterophilic cell-cell adhesion
GO:0007159	leukocyte cell-cell adhesion
GO:0007569	cell aging
GO:0007605	sensory perception of sound
GO:0008360	regulation of cell shape
GO:0009615	response to virus
GO:0010212	response to ionizing radiation
GO:0010477	response to sulfur dioxide
GO:0014070	response to organic cyclic compound
GO:0016337	single organismal cell-cell adhesion
GO:0019221	cytokine-mediated signaling pathway
GO:0022614	membrane to membrane docking
GO:0030155	regulation of cell adhesion
GO:0030198	extracellular matrix organization
GO:0030838	positive regulation of actin filament polymerization
GO:0031669	cellular response to nutrient levels
GO:0032321	positive regulation of Rho GTPase activity
GO:0032496	response to lipopolysaccharide
GO:0033627	cell adhesion mediated by integrin
GO:0034698	response to gonadotropin
GO:0042493	response to drug
GO:0043200	response to amino acid
GO:0044406	adhesion of symbiont to host
GO:0045087	innate immune response (InnateDB)
GO:0045429	positive regulation of nitric oxide biosynthetic process
GO:0045471	response to ethanol
GO:0045907	positive regulation of vasoconstriction
GO:0046688	response to copper ion
GO:0046813	receptor-mediated virion attachment to host cell
GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation
GO:0050776	regulation of immune response
GO:0050900	leukocyte migration
GO:0051092	positive regulation of NF-kappaB transcription factor activity
GO:0051926	negative regulation of calcium ion transport
GO:0060333	interferon-gamma-mediated signaling pathway
GO:0061028	establishment of endothelial barrier
GO:0070374	positive regulation of ERK1 and ERK2 cascade
GO:0071222	cellular response to lipopolysaccharide
GO:0071310	cellular response to organic substance
GO:0071312	cellular response to alkaloid
GO:0071333	cellular response to glucose stimulus
GO:0071347	cellular response to interleukin-1
GO:0071356	cellular response to tumor necrosis factor
GO:0071456	cellular response to hypoxia
GO:0097368	establishment of Sertoli cell barrier
GO:1900027	regulation of ruffle assembly
GO:1902042	negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
GO:2000352	negative regulation of endothelial cell apoptotic process

Cellular Component

GO:0001772	immunological synapse
GO:0005615	extracellular space
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0009897	external side of plasma membrane
GO:0009986	cell surface
GO:0016020	membrane
GO:0070062	extracellular vesicular exosome