Version 5.4
Homo sapiens Gene: ICAM3
Summary
InnateDB Gene IDBG-27123.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ICAM3
Gene Name intercellular adhesion molecule 3
Synonyms CD50; CDW50; ICAM-R
Species Homo sapiens
Ensembl Gene ENSG00000076662
Encoded Proteins
IDBP-27125
intercellular adhesion molecule 3
IDBP-760963
IDBP-760444
IDBP-764409
IDBP-760857
IDBP-765947
IDBP-766216
IDBP-761607
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein is constitutively and abundantly expressed by all leucocytes and may be the most important ligand for LFA-1 in the initiation of the immune response. It functions not only as an adhesion molecule, but also as a potent signalling molecule. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 19:10333776-10339823
Strand Reverse strand
Band p13.2
Transcripts
ENST00000160262 ENSP00000160262
ENST00000585439 ENSP00000466501
ENST00000589580 ENSP00000468282
ENST00000589249 ENSP00000466081
ENST00000592439 ENSP00000467232
ENST00000589261 ENSP00000468333
ENST00000590569 ENSP00000467770
ENST00000592945 ENSP00000468230
ENST00000587992
ENST00000589900
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005102 receptor binding
GO:0005178 integrin binding
GO:0005515 protein binding
Biological Process
GO:0016337 single organismal cell-cell adhesion
GO:0030198 extracellular matrix organization
GO:0050776 regulation of immune response
Cellular Component
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_11152
Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell pathway
REACT_13552
Integrin cell surface interactions pathway
REACT_118779
Extracellular matrix organization pathway
REACT_75774
Adaptive Immune System pathway
REACT_6900
Immune System pathway
KEGG
hsa04514
Cell adhesion molecules (CAMs) pathway
INOH
PID NCI
integrin2_pathway
Beta2 integrin cell surface interactions
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.654563
RefSeq NM_002162
HUGO
OMIM
CCDS CCDS12235
HPRD 00889
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca