Version 5.4
Homo sapiens Gene: STX1B
Summary
InnateDB Gene IDBG-27543.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol STX1B
Gene Name syntaxin 1B
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000099365
Encoded Proteins
IDBP-27545
syntaxin 1B
IDBP-752862
IDBP-750529
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Syntaxins are cellular receptors for transport vesicles (see MIM 603765). One of these proteins, designated syntaxin 1B (STX1B), is directly implicated in the process of calcium-dependent synaptic transmission in rat brain (Smirnova et al., 1993 [PubMed 8105537]). The expression of this protein is transiently induced by long-term potentiation of synaptic responses in the rat hippocampus. The protein may play an important role in the excitatory pathway of synaptic transmission, which is known to be implicated in several neurologic diseases.[supplied by OMIM, Nov 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:30989256-31010628
Strand Reverse strand
Band p11.2
Transcripts
ENST00000215095 ENSP00000215095
ENST00000566211
ENST00000561836
ENST00000569638 ENSP00000457067
ENST00000565419 ENSP00000455899
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 10 [view]
Protein-Protein 10 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000149 SNARE binding
GO:0005230 extracellular ligand-gated ion channel activity
GO:0005234 extracellular-glutamate-gated ion channel activity
GO:0005484 SNAP receptor activity
GO:0005515 protein binding
GO:0019901 protein kinase binding
GO:0019904 protein domain specific binding
Biological Process
GO:0006810 transport
GO:0006836 neurotransmitter transport
GO:0006886 intracellular protein transport
GO:0007268 synaptic transmission
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0017157 regulation of exocytosis
GO:0034220 ion transmembrane transport
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005815 microtubule organizing center
GO:0005819 spindle
GO:0005887 integral component of plasma membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000030806
View Gene Order
ENSBTAG00000002349
Not yet available
Pathways
NETPATH
REACTOME
REACT_11184
Neurotoxicity of clostridium toxins pathway
REACT_228211
Uptake and actions of bacterial toxins pathway
REACT_116125
Disease pathway
REACT_200658
Toxicity of botulinum toxin type C (BoNT/C) pathway
KEGG
hsa04130
SNARE interactions in vesicular transport pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.542230
RefSeq NM_052874
HUGO
OMIM
CCDS CCDS10699
HPRD 18126
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca