Version 5.4
Homo sapiens Gene: ALOX15B
Summary
InnateDB Gene IDBG-27642.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ALOX15B
Gene Name arachidonate 15-lipoxygenase, type B
Synonyms 15-LOX-2
Species Homo sapiens
Ensembl Gene ENSG00000179593
Encoded Proteins
IDBP-27644
arachidonate 15-lipoxygenase, type B
IDBP-27648
arachidonate 15-lipoxygenase, type B
IDBP-763957
IDBP-760699
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the lipoxygenase family of structurally related nonheme iron dioxygenases involved in the production of fatty acid hydroperoxides. The encoded protein converts arachidonic acid exclusively to 15S-hydroperoxyeicosatetraenoic acid, while metabolizing linoleic acid less effectively. This gene is located in a cluster of related genes and a pseudogene that spans approximately 100 kilobases on the short arm of chromosome 17. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:8039017-8049134
Strand Forward strand
Band p13.1
Transcripts
ENST00000380183 ENSP00000369530
ENST00000380173 ENSP00000369520
ENST00000572022 ENSP00000458749
ENST00000573359 ENSP00000460332
ENST00000571240
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
Experimentally validated
Total 3 [view]
Protein-Protein 3 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005506 iron ion binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0008289 lipid binding
GO:0016165 lipoxygenase activity
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0036403 arachidonate 8(S)-lipoxygenase activity
GO:0046872 metal ion binding
GO:0050473 arachidonate 15-lipoxygenase activity
Biological Process
GO:0006629 lipid metabolic process
GO:0006915 apoptotic process
GO:0008285 negative regulation of cell proliferation
GO:0010744 positive regulation of macrophage derived foam cell differentiation
GO:0019369 arachidonic acid metabolic process
GO:0019372 lipoxygenase pathway
GO:0030336 negative regulation of cell migration
GO:0030850 prostate gland development
GO:0030856 regulation of epithelial cell differentiation
GO:0035360 positive regulation of peroxisome proliferator activated receptor signaling pathway
GO:0043651 linoleic acid metabolic process
GO:0044281 small molecule metabolic process
GO:0045618 positive regulation of keratinocyte differentiation
GO:0045786 negative regulation of cell cycle
GO:0045926 negative regulation of growth
GO:0051122 hepoxilin biosynthetic process
GO:0055114 oxidation-reduction process
GO:0090197 positive regulation of chemokine secretion
Cellular Component
GO:0005622 intracellular
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005856 cytoskeleton
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0019898 extrinsic component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020891
View Gene Order
ENSBTAG00000008779
Not yet available
Pathways
NETPATH
REACTOME
REACT_150422
Synthesis of 15-eicosatetraenoic acid derivatives pathway
REACT_147851
Arachidonic acid metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00590
Arachidonic acid metabolism pathway
INOH
INOH website
Prostaglandin Leukotriene metabolism pathway
PID NCI
Cross-References
SwissProt O15296
TrEMBL
UniProt Splice Variant
Entrez Gene 247
UniGene Hs.111256
RefSeq NM_001039130 NM_001039131 NM_001141
HUGO HGNC:434
OMIM 603697
CCDS CCDS32558 CCDS11128 CCDS32559
HPRD 04739
IMGT
EMBL AC129492 AF149095 AF468051 AF468052 AF468053 AF468054 AJ305028 AJ305029 AJ305030 AJ305031 BC035217 BC063647 CH471108 U78294
GenPept AAB61706 AAD37786 AAH35217 AAH63647 AAL76274 AAL76275 AAL76276 AAL76277 CAC34521 EAW90098 EAW90100
RNA Seq Atlas 247

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca