InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: ADAM17

Summary

InnateDB Gene

IDBG-27788.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ADAM17

Gene Name

ADAM metallopeptidase domain 17

Synonyms

ADAM18; CD156B; CSVP; NISBD; TACE

Species

Homo sapiens

Ensembl Gene

ENSG00000151694

Encoded Proteins

IDBP-27792

ADAM metallopeptidase domain 17

IDBP-484891

ADAM metallopeptidase domain 17

IDBP-812589

ADAM metallopeptidase domain 17

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation from Orthologs

Summary

PMID 25461404

[Mus musculus] Adam17 affects sensitivity to interleukin-1 by changing the balance between Il1r1 and Il1r2 receptors.

Entrez Gene

Summary

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biologic processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene functions as a tumor necrosis factor-alpha converting enzyme; binds mitotic arrest deficient 2 protein; and also plays a prominent role in the activation of the Notch signaling pathway. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:9488486-9555792

Strand

Reverse strand

Band

p25.1

Transcripts

ENST00000310823	ENSP00000309968
ENST00000497134	ENSP00000418728
ENST00000478059
ENST00000618923	ENSP00000480552

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	27 [view]
Protein-Protein	26 [view]
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004222	metalloendopeptidase activity
GO:0005112	Notch binding
GO:0005138	interleukin-6 receptor binding
GO:0005178	integrin binding
GO:0005515	protein binding
GO:0008237	metallopeptidase activity
GO:0008270	zinc ion binding
GO:0017124	SH3 domain binding
GO:0030165	PDZ domain binding

Biological Process

GO:0001666	response to hypoxia
GO:0001934	positive regulation of protein phosphorylation
GO:0002446	neutrophil mediated immunity
GO:0002467	germinal center formation
GO:0002690	positive regulation of leukocyte chemotaxis
GO:0006508	proteolysis
GO:0006509	membrane protein ectodomain proteolysis
GO:0006915	apoptotic process
GO:0007155	cell adhesion
GO:0007173	epidermal growth factor receptor signaling pathway
GO:0007219	Notch signaling pathway
GO:0007220	Notch receptor processing
GO:0008284	positive regulation of cell proliferation
GO:0010820	positive regulation of T cell chemotaxis
GO:0022617	extracellular matrix disassembly
GO:0030183	B cell differentiation
GO:0030198	extracellular matrix organization
GO:0030307	positive regulation of cell growth
GO:0030335	positive regulation of cell migration
GO:0030511	positive regulation of transforming growth factor beta receptor signaling pathway
GO:0030512	negative regulation of transforming growth factor beta receptor signaling pathway
GO:0030574	collagen catabolic process
GO:0031293	membrane protein intracellular domain proteolysis
GO:0031659	positive regulation of cyclin-dependent protein kinase activity involved in G1/S
GO:0032496	response to lipopolysaccharide
GO:0032717	negative regulation of interleukin-8 production
GO:0032722	positive regulation of chemokine production
GO:0033025	regulation of mast cell apoptotic process
GO:0033077	T cell differentiation in thymus
GO:0033627	cell adhesion mediated by integrin
GO:0035313	wound healing, spreading of epidermal cells
GO:0035625	epidermal growth factor-activated receptor transactivation by G-protein coupled receptor signaling pathway
GO:0042493	response to drug
GO:0045741	positive regulation of epidermal growth factor-activated receptor activity
GO:0048011	neurotrophin TRK receptor signaling pathway
GO:0048536	spleen development
GO:0048870	cell motility
GO:0051088	PMA-inducible membrane protein ectodomain proteolysis
GO:0051272	positive regulation of cellular component movement
GO:0055099	response to high density lipoprotein particle stimulus
GO:0060397	JAK-STAT cascade involved in growth hormone signaling pathway
GO:0097190	apoptotic signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005886	plasma membrane
GO:0005887	integral component of plasma membrane
GO:0005911	cell-cell junction
GO:0005925	focal adhesion
GO:0009986	cell surface
GO:0015629	actin cytoskeleton
GO:0016020	membrane
GO:0016324	apical plasma membrane
GO:0032587	ruffle membrane
GO:0045121	membrane raft