Version 5.4
Homo sapiens Gene: ALOX12B
Summary
InnateDB Gene IDBG-27811.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ALOX12B
Gene Name arachidonate 12-lipoxygenase, 12R type
Synonyms 12R-LOX; ARCI2
Species Homo sapiens
Ensembl Gene ENSG00000179477
Encoded Proteins
IDBP-27815
arachidonate 12-lipoxygenase, 12R type
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes an enzyme involved in the converstion of arachidonic acid to 12R-hydroxyeicosatetraenoic acid. Mutations in this gene are associated with nonbullous congenital ichthyosiform erythroderma. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:8072636-8087703
Strand Reverse strand
Band p13.1
Transcripts
ENST00000319144 ENSP00000315167
ENST00000583276
ENST00000584116
ENST00000577351
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004052 arachidonate 12-lipoxygenase activity
GO:0005506 iron ion binding
GO:0005515 protein binding
GO:0016702 oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen
GO:0046872 metal ion binding
GO:1990136 linoleate 9S-lipoxygenase activity
Biological Process
GO:0006497 protein lipidation
GO:0006665 sphingolipid metabolic process
GO:0010628 positive regulation of gene expression
GO:0019369 arachidonic acid metabolic process
GO:0019372 lipoxygenase pathway
GO:0043410 positive regulation of MAPK cascade
GO:0043651 linoleic acid metabolic process
GO:0044281 small molecule metabolic process
GO:0046513 ceramide biosynthetic process
GO:0051122 hepoxilin biosynthetic process
GO:0055114 oxidation-reduction process
GO:0061436 establishment of skin barrier
GO:0070257 positive regulation of mucus secretion
Cellular Component
GO:0005829 cytosol
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000032807
View Gene Order
ENSBTAG00000012475
Not yet available
Pathways
NETPATH
REACTOME
REACT_150201
Synthesis of 12-eicosatetraenoic acid derivatives pathway
REACT_147851
Arachidonic acid metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_111217
Metabolism pathway
KEGG
hsa00590
Arachidonic acid metabolism pathway
INOH
PID NCI
il23pathway
IL23-mediated signaling events
Cross-References
SwissProt O75342
TrEMBL
UniProt Splice Variant
Entrez Gene 242
UniGene Hs.136574
RefSeq NM_001139
HUGO HGNC:430
OMIM 603741
CCDS CCDS11129
HPRD
IMGT
EMBL AF038461 AF059250 AJ305026 AJ305027 BC041058
GenPept AAC39770 AAC79680 AAH41058 CAC34520
RNA Seq Atlas 242

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca