InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: YWHAQ

Summary

InnateDB Gene

IDBG-27933.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

YWHAQ

Gene Name

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide

Synonyms

14-3-3; 1C5; HS1

Species

Homo sapiens

Ensembl Gene

ENSG00000134308

Encoded Proteins

IDBP-27935

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide

IDBP-27937

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide

IDBP-363080

tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008]
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99%% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5\' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 2:9583972-9631014

Strand

Reverse strand

Band

p25.1

Transcripts

ENST00000381844	ENSP00000371267
ENST00000238081	ENSP00000238081
ENST00000446619	ENSP00000398990
ENST00000474715
ENST00000460093

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 518 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.

Experimentally validated
Total	518 [view]
Protein-Protein	516 [view]
Protein-DNA	0
Protein-RNA	1 [view]
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	15 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0019904	protein domain specific binding
GO:0047485	protein N-terminus binding
GO:0071889	14-3-3 protein binding

Biological Process

GO:0006605	protein targeting
GO:0006915	apoptotic process
GO:0007264	small GTPase mediated signal transduction
GO:0021762	substantia nigra development
GO:0045892	negative regulation of transcription, DNA-templated
GO:0061024	membrane organization
GO:0097193	intrinsic apoptotic signaling pathway
GO:1900740	positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway

Cellular Component

GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0016020	membrane
GO:0030659	cytoplasmic vesicle membrane
GO:0043234	protein complex
GO:0070062	extracellular vesicular exosome