Homo sapiens Gene: YWHAQ | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Gene | IDBG-27933.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | YWHAQ | ||||||||||||||||||||||
Gene Name | tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide | ||||||||||||||||||||||
Synonyms | 14-3-3; 1C5; HS1 | ||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||
Ensembl Gene | ENSG00000134308 | ||||||||||||||||||||||
Encoded Proteins |
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, theta polypeptide
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Protein Structure | |||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
Summary |
This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008] This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 99%% identical to the mouse and rat orthologs. This gene is upregulated in patients with amyotrophic lateral sclerosis. It contains in its 5\' UTR a 6 bp tandem repeat sequence which is polymorphic, however, there is no correlation between the repeat number and the disease. [provided by RefSeq, Jul 2008] |
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Gene Information | |||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||
Genomic Location | Chromosome 2:9583972-9631014 | ||||||||||||||||||||||
Strand | Reverse strand | ||||||||||||||||||||||
Band | p25.1 | ||||||||||||||||||||||
Transcripts |
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Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 518 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||
NETPATH |
Alpha6Beta4Integrin pathway
TNFalpha pathway
TCR pathway
IL3 pathway
FSH pathway
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REACTOME |
Activation of BAD and translocation to mitochondria pathway
Translocation of GLUT4 to the plasma membrane pathway
Apoptosis pathway
Activation of BH3-only proteins pathway
Intrinsic Pathway for Apoptosis pathway
Membrane Trafficking pathway
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KEGG |
Pathogenic Escherichia coli infection pathway
Cell cycle pathway
Oocyte meiosis pathway
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INOH |
IL-7 signaling pathway
EPO signaling pathway pathway
Wnt signaling pathway pathway
Insulin receptor signaling pathway
Fas signaling pathway pathway
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PID NCI |
Role of Calcineurin-dependent NFAT signaling in lymphocytes
Validated transcriptional targets of TAp63 isoforms
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Cross-References | |||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||
UniGene | Hs.74405 | ||||||||||||||||||||||
RefSeq | NM_006826 | ||||||||||||||||||||||
HUGO | |||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS1666 | ||||||||||||||||||||||
HPRD | 00886 | ||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | |||||||||||||||||||||||
GenPept | |||||||||||||||||||||||
RNA Seq Atlas | |||||||||||||||||||||||