Version 5.4
Homo sapiens Gene: CKLF
Summary
InnateDB Gene IDBG-281643.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CKLF
Gene Name chemokine-like factor
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000217555
Encoded Proteins
IDBP-35056
chemokine-like factor
IDBP-35058
chemokine-like factor
IDBP-35060
chemokine-like factor
IDBP-35062
chemokine-like factor
IDBP-378488
chemokine-like factor
IDBP-598698
chemokine-like factor
IDBP-596882
chemokine-like factor
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene is a cytokine. Cytokines are small proteins that have an essential role in the immune and inflammatory responses. This gene is one of several chemokine-like factor genes located in a cluster on chromosome 16. The protein encoded by this gene is a potent chemoattractant for neutrophils, monocytes and lymphocytes. It also can stimulate the proliferation of skeletal muscle cells. This protein may play important roles in inflammation and in the regeneration of skeletal muscle. Alternatively spliced transcript variants encoding different isoforms have been identified. Naturally occurring read-through transcription occurs between this locus and the neighboring locus CMTM1 (CKLF-like MARVEL transmembrane domain containing 1).[provided by RefSeq, Feb 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:66552563-66566251
Strand Forward strand
Band q21
Transcripts
ENST00000264001 ENSP00000264001
ENST00000345436 ENSP00000290771
ENST00000351137 ENSP00000264003
ENST00000362093 ENSP00000355417
ENST00000417030 ENSP00000416678
ENST00000534692 ENSP00000431270
ENST00000526149
ENST00000532838 ENSP00000433857
ENST00000563092
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0008009 chemokine activity
Biological Process
GO:0008283 cell proliferation
GO:0030593 neutrophil chemotaxis
GO:0030595 leukocyte chemotaxis
GO:0032940 secretion by cell
GO:0048246 macrophage chemotaxis
GO:0048247 lymphocyte chemotaxis
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space
GO:0016020 membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000054400
View Gene Order
ENSBTAG00000038858
Not yet available
Cross-References
SwissProt
TrEMBL E9PLU7
UniProt Splice Variant
Entrez Gene 51192
UniGene
RefSeq NM_001040138 NM_016326 NM_016951 NM_181640 NM_181641 NM_001202509 NM_001204098 NM_001204099
HUGO HGNC:13253
OMIM
CCDS CCDS10806 CCDS10807 CCDS10808 CCDS10809 CCDS45502 CCDS56000 CCDS73898 CCDS73899
HPRD 16718
IMGT
EMBL AC010542
GenPept
RNA Seq Atlas 51192

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca