Homo sapiens Gene: GGT1 | |||||||||||||||||||||||||||||||||||
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Summary | |||||||||||||||||||||||||||||||||||
InnateDB Gene | IDBG-2905.6 | ||||||||||||||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||||||||||||||
Gene Symbol | GGT1 | ||||||||||||||||||||||||||||||||||
Gene Name | gamma-glutamyltransferase 1 | ||||||||||||||||||||||||||||||||||
Synonyms | CD224; D22S672; D22S732; GGT; GGT 1; GTG | ||||||||||||||||||||||||||||||||||
Species | Homo sapiens | ||||||||||||||||||||||||||||||||||
Ensembl Gene | ENSG00000100031 | ||||||||||||||||||||||||||||||||||
Encoded Proteins |
gamma-glutamyltransferase 1
gamma-glutamyltransferase 1
gamma-glutamyltransferase 1
gamma-glutamyltransferase 1
gamma-glutamyltransferase 1
gamma-glutamyltransferase 1
gamma-glutamyltransferase 1
gamma-glutamyltransferase 1
gamma-glutamyltransferase 1
gamma-glutamyltransferase 1
gamma-glutamyltransferase 1
gamma-glutamyltransferase 1
gamma-glutamyltransferase 1
gamma-glutamyltransferase 1
gamma-glutamyltransferase 1
gamma-glutamyltransferase 1
gamma-glutamyltransferase 1
gamma-glutamyltransferase 1
gamma-glutamyltransferase 1
gamma-glutamyltransferase 1
gamma-glutamyltransferase 1
gamma-glutamyltransferase 1
gamma-glutamyltransferase 1
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Protein Structure | |||||||||||||||||||||||||||||||||||
Useful resources | Stemformatics EHFPI ImmGen | ||||||||||||||||||||||||||||||||||
Entrez Gene | |||||||||||||||||||||||||||||||||||
Summary |
GGT2 belongs to the gamma-glutamyltransferase (GGT; EC 2.3.2.2) gene family. GGT is a membrane-bound extracellular enzyme that cleaves gamma-glutamyl peptide bonds in glutathione and other peptides and transfers the gamma-glutamyl moiety to acceptors. GGT is also key to glutathione homeostasis because it provides substrates for glutathione synthesis (Heisterkamp et al., 2008 [PubMed 18357469]).[supplied by OMIM, Oct 2008] The enzyme encoded by this gene catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. The enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein, and is present in tissues involved in absorption and secretion. This enzyme is a member of the gamma-glutamyltransferase protein family, of which many members have not yet been fully characterized and some of which may represent pseudogenes. This gene is classified as type I gamma-glutamyltransferase. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Oct 2008] The enzyme encoded by this gene is a type I gamma-glutamyltransferase that catalyzes the transfer of the glutamyl moiety of glutathione to a variety of amino acids and dipeptide acceptors. The enzyme is composed of a heavy chain and a light chain, which are derived from a single precursor protein. It is expressed in tissues involved in absorption and secretion and may contribute to the etiology of diabetes and other metabolic disorders. Multiple alternatively spliced variants have been identified. There are a number of related genes present on chromosomes 20 and 22, and putative pseudogenes for this gene on chromosomes 2, 13, and 22. [provided by RefSeq, Jan 2014] |
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Gene Information | |||||||||||||||||||||||||||||||||||
Type | Protein coding | ||||||||||||||||||||||||||||||||||
Genomic Location | Chromosome 22:24583750-24629005 | ||||||||||||||||||||||||||||||||||
Strand | Forward strand | ||||||||||||||||||||||||||||||||||
Band | q11.23 | ||||||||||||||||||||||||||||||||||
Transcripts | |||||||||||||||||||||||||||||||||||
Interactions | |||||||||||||||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
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Gene Ontology | |||||||||||||||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Orthologs | |||||||||||||||||||||||||||||||||||
Species
Mus musculus
Bos taurus
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Gene ID
Gene Order
Not yet available
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Pathways | |||||||||||||||||||||||||||||||||||
NETPATH | |||||||||||||||||||||||||||||||||||
REACTOME |
Synthesis of Leukotrienes (LT) and Eoxins (EX) pathway
Arachidonic acid metabolism pathway
Glutathione synthesis and recycling pathway
Glutathione conjugation pathway
Metabolism of lipids and lipoproteins pathway
Aflatoxin activation and detoxification pathway
Phase II conjugation pathway
Metabolism pathway
Biological oxidations pathway
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KEGG |
Arachidonic acid metabolism pathway
Cyanoamino acid metabolism pathway
Taurine and hypotaurine metabolism pathway
Glutathione metabolism pathway
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INOH |
Prostaglandin Leukotriene metabolism pathway
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PID NCI | |||||||||||||||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||||||||||||||
SwissProt | |||||||||||||||||||||||||||||||||||
TrEMBL | C9JGF3 C9JIY6 E7ERN9 E7ETN1 E9PHP2 O75693 | ||||||||||||||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||||||||||||||
Entrez Gene | 92086 | ||||||||||||||||||||||||||||||||||
UniGene | Hs.450000 Hs.645535 | ||||||||||||||||||||||||||||||||||
RefSeq | NM_001282879 NM_001288833 NM_013421 NM_013430 XM_005260863 XM_005260864 XM_005261815 XM_005261817 XM_005261888 XM_005261890 XM_006723661 XM_006724365 XM_006724392 XM_006724394 XM_006724395 XM_006724396 XM_006724397 XM_006724924 XM_006724925 XM_006724926 XM_006724927 XM_006724928 XM_006724929 | ||||||||||||||||||||||||||||||||||
HUGO | HGNC:4250 | ||||||||||||||||||||||||||||||||||
OMIM | 137181 612338 612339 612346 | ||||||||||||||||||||||||||||||||||
CCDS | CCDS42992 | ||||||||||||||||||||||||||||||||||
HPRD | 01980 | ||||||||||||||||||||||||||||||||||
IMGT | |||||||||||||||||||||||||||||||||||
EMBL | AJ007493 AP000356 | ||||||||||||||||||||||||||||||||||
GenPept | CAA07536 | ||||||||||||||||||||||||||||||||||
RNA Seq Atlas | 102724197 2678 728441 91227 92086 | ||||||||||||||||||||||||||||||||||