Version 5.4
Homo sapiens Gene: IQGAP2
Summary
InnateDB Gene IDBG-29509.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol IQGAP2
Gene Name IQ motif containing GTPase activating protein 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000145703
Encoded Proteins
IDBP-29511
IQ motif containing GTPase activating protein 2
IDBP-591514
IQ motif containing GTPase activating protein 2
IDBP-237917
IQ motif containing GTPase activating protein 2
IDBP-475854
IQ motif containing GTPase activating protein 2
IDBP-473885
IQ motif containing GTPase activating protein 2
IDBP-480091
IQ motif containing GTPase activating protein 2
IDBP-475850
IQ motif containing GTPase activating protein 2
IDBP-477859
IQ motif containing GTPase activating protein 2
IDBP-479549
IQ motif containing GTPase activating protein 2
IDBP-475537
IQ motif containing GTPase activating protein 2
IDBP-482494
IQ motif containing GTPase activating protein 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the IQGAP family. The protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:76403249-76708132
Strand Forward strand
Band q13.3
Transcripts
ENST00000274364 ENSP00000274364
ENST00000379730 ENSP00000442313
ENST00000396234 ENSP00000379535
ENST00000514350 ENSP00000423672
ENST00000505766 ENSP00000421097
ENST00000504815
ENST00000514001 ENSP00000422661
ENST00000509074 ENSP00000425351
ENST00000502745 ENSP00000426027
ENST00000504254 ENSP00000423258
ENST00000513534 ENSP00000421319
ENST00000515505
ENST00000514579
ENST00000512383
ENST00000504558
ENST00000504477 ENSP00000425941
ENST00000509741
ENST00000512256
ENST00000508410
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
Experimentally validated
Total 13 [view]
Protein-Protein 13 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005095 GTPase inhibitor activity
GO:0005096 GTPase activator activity
GO:0005099 Ras GTPase activator activity
GO:0005515 protein binding
GO:0005516 calmodulin binding
GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding
Biological Process
GO:0007165 signal transduction
GO:0007264 small GTPase mediated signal transduction
GO:0032320 positive regulation of Ras GTPase activity
GO:0043086 negative regulation of catalytic activity
GO:0043547 positive regulation of GTPase activity
GO:0051056 regulation of small GTPase mediated signal transduction
Cellular Component
GO:0005622 intracellular
GO:0005874 microtubule
GO:0005902 microvillus
GO:0015629 actin cytoskeleton
GO:0070062 extracellular vesicular exosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021676
View Gene Order
ENSBTAG00000000897
Not yet available
Pathways
NETPATH
NetPath_9
TNFalpha pathway
REACTOME
KEGG
hsa04810
Regulation of actin cytoskeleton pathway
INOH
PID NCI
Cross-References
SwissProt Q13576
TrEMBL D6R939 D6R999 D6RDK8 D6RGC6 E7EWC2 E9PDT6 H0YA28
UniProt Splice Variant
Entrez Gene 10788
UniGene Hs.291030
RefSeq NM_001285460 NM_001285461 NM_001285462 NM_006633 XM_005248409 XM_005248410 XM_005248411 XM_005248414 XM_006714522
HUGO HGNC:6111
OMIM 605401
CCDS CCDS34188 CCDS68897 CCDS68898 CCDS75262
HPRD
IMGT
EMBL AC025188 AC026706 AC026725 AC093251 AC112173 AK291066 AK303054 AY351902 U51903
GenPept AAB37765 AAQ81291 BAF83755 BAH13890
RNA Seq Atlas 10788

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca