Version 5.4
Homo sapiens Gene: ECSIT
Summary
InnateDB Gene IDBG-29564.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ECSIT
Gene Name ECSIT homolog (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000130159
Encoded Proteins
IDBP-29566
ECSIT homolog (Drosophila)
IDBP-29568
ECSIT homolog (Drosophila)
IDBP-372456
ECSIT homolog (Drosophila)
IDBP-761884
IDBP-762954
IDBP-763512
IDBP-761475
IDBP-762770
IDBP-760637
IDBP-765804
IDBP-765680
IDBP-760194
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
PMID 10465784
ECSIT is specific for the Toll/IL-1 pathways and is a regulator of MAP3K1 (MEKK1) processing.
PMID 25371197
ECSIT binds to MAP3K7 and TRAF6 to form a complex that plays a pivotal role in activating TLR4-mediated NF-kB signalling.
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 19:11505916-11529174
Strand Reverse strand
Band p13.2
Transcripts
ENST00000270517 ENSP00000270517
ENST00000252440 ENSP00000252440
ENST00000417981 ENSP00000412712
ENST00000586149 ENSP00000466415
ENST00000592665 ENSP00000465181
ENST00000591352
ENST00000588998 ENSP00000468783
ENST00000585898
ENST00000593231 ENSP00000464783
ENST00000592312 ENSP00000466762
ENST00000591104 ENSP00000466559
ENST00000590480 ENSP00000467436
ENST00000592571 ENSP00000465162
ENST00000585318 ENSP00000462957
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 53 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 53 [view]
Protein-Protein 52 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004871 signal transducer activity
GO:0005515 protein binding
GO:0016651 oxidoreductase activity, acting on NAD(P)H
Biological Process
GO:0001707 mesoderm formation
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0007178 transmembrane receptor protein serine/threonine kinase signaling pathway
GO:0030509 BMP signaling pathway
GO:0045087 innate immune response (InnateDB)
GO:0051341 regulation of oxidoreductase activity
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005634 nucleus
GO:0005667 transcription factor complex
GO:0005737 cytoplasm
GO:0005739 mitochondrion
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000066839
View Gene Order
ENSBTAG00000015049
Not yet available
Pathways
NETPATH
NetPath_13
IL1 pathway
REACTOME
KEGG
hsa04010
MAPK signaling pathway pathway
INOH
INOH website
Toll-like receptor signaling pathway pathway
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.738470
RefSeq NM_001142464 NM_001142465 NM_001243204 NM_016581
HUGO
OMIM
CCDS CCDS12262 CCDS45979 CCDS45980 CCDS59353
HPRD 12225
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca