Homo sapiens Gene: PYURF
Summary
InnateDB Gene IDBG-29835.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol PYURF
Gene Name PIGY upstream reading frame
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000145337
Encoded Proteins
phosphatidylinositol glycan anchor biosynthesis, class Y
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The product of this gene, which is well-conserved, is encoded by the same bicistronic transcript that encodes phosphatidylinositol glycan anchor biosynthesis, class Y, but the two proteins are unrelated. This gene represents the protein encoded by the upstream open reading frame, while the protein encoded by the downstream open reading frame is represented by GeneID:84992. [provided by RefSeq, Aug 2012] The protein encoded by this gene is part of the GPI-N-acetylglucosaminyltransferase (GIP-GnT) complex which initiates the biosynthesis of glycosylphosphatidylinositol (GPI). GPI is synthesized in the endoplasmic reticulum and serves as an anchor for many surface proteins. Proteins containing GPI anchors can have an important role in cell-cell interactions. The transcript for this gene is bicistronic. The downstream open reading frame encodes this GPI-GnT complex protein, while the upstream open reading frame encodes a protein with unknown function, as represented by GeneID:100996939. [provided by RefSeq, Aug 2012]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:88520985-88523813
Strand Reverse strand
Band q22.1
Transcripts
ENST00000273968 ENSP00000273968
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0006506 GPI anchor biosynthetic process
GO:0009893 positive regulation of metabolic process
Cellular Component
GO:0000506 glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex
GO:0005739 mitochondrion
GO:0005789 endoplasmic reticulum membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Pathways
NETPATH
REACTOME
KEGG
Glycosylphosphatidylinositol(GPI)-anchor biosynthesis pathway
INOH
PID NCI
Cross-References
SwissProt Q96I23
TrEMBL
UniProt Splice Variant
Entrez Gene 84992
UniGene Hs.26136 Hs.743393
RefSeq NM_032906
HUGO HGNC:44317
OMIM 610662
CCDS CCDS3631
HPRD
IMGT
EMBL AB206972 AK312082 BC007876
GenPept BAG35018
RNA Seq Atlas 100996939 84992