InnateDB Gene
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IDBG-299327.5
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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MYCNOS
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Gene Name
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MYCN opposite strand/antisense RNA
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Synonyms
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MYCN-AS1; N-CYM; NCYM; NYCM
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Species
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Homo sapiens
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Ensembl Gene
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ENSG00000233718
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Encoded Proteins
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Protein Structure
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Useful resources
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Stemformatics
EHFPI
ImmGen
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Summary |
The N-myc oncogene has been implicated in the pathogenesis of a number of human tumors, including childhood neuroblastoma and adult small cell lung cancer. Complementary DNA clones derived from a transcription unit, N-cym, located on the opposite DNA strand to N-myc have been characterized. There is extensive overlap between the 5' ends of the two transcription units. The N-cym gene, which can encode a 109-amino acid protein, is expressed during fetal development, as well as in tumor cell lines containing amplified N-myc loci, where it is expressed at very high levels. Although other examples of overlapping, opposite-strand eukaryotic genes exist, N-myc and N-cym are unique in that they appear to be coregulated in tumor cell lines under basal growth conditions and in response to the differentiating agent retinoic acid. This coregulation suggests that their protein products may be functionally interrelated during normal development and oncogenesis. [provided by RefSeq, Jul 2008]
This gene is located on the opposite strand of v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog (GeneID 4613). Transcription of this antisense gene may influence the progression of neuroblastoma by inhibiting transcription of v-myc avian myelocytomatosis viral oncogene neuroblastoma derived homolog. This gene is represented as non-coding pending further experimental evidence of a protein product. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jan 2014]
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Type |
antisense
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Genomic Location
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Chromosome 2:15921037-15942249
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Strand
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Reverse strand
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Band
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p24.3
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Transcripts
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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No orthologs found for this gene |
SwissProt
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TrEMBL
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UniProt Splice Variant
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Entrez Gene
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UniGene
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Hs.651453
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RefSeq
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HUGO
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OMIM
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CCDS
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HPRD |
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IMGT
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EMBL
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GenPept
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RNA Seq Atlas
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