Homo sapiens Gene: NLRP14
Summary
InnateDB Gene IDBG-29985.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NLRP14
Gene Name NLR family, pyrin domain containing 14
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000158077
Encoded Proteins
NLR family, pyrin domain containing 14
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
InnateDB Annotation
Summary
Part of the NLRP (Nucleotide-binding oligomerization domain, Leucine rich Repeat and Pyrin domain containing) family, has a role in apoptosis and inflammation and several NLRPs have been indicated as being involved in reproduction as well
Entrez Gene
Summary The protein encoded by this gene belongs to the NALP protein family. Members of the NALP protein family typically contain a NACHT domain, a NACHT-associated domain (NAD), a C-terminal leucine-rich repeat (LRR) region, and an N-terminal pyrin domain (PYD). This protein may play a regulatory role in the innate immune system as similar family members belong to the signal-induced multiprotein complex, the inflammasome, that activates the pro-inflammatory caspases, caspase-1 and caspase-5. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:7020446-7071308
Strand Forward strand
Band p15.4
Transcripts
ENST00000299481 ENSP00000299481
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005524 ATP binding
Biological Process
GO:0007275 multicellular organismal development
GO:0007283 spermatogenesis
GO:0030154 cell differentiation
GO:0045087 innate immune response (InnateDB)
Cellular Component
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
Not yet available
Cross-References
SwissProt Q86W24
TrEMBL
UniProt Splice Variant
Entrez Gene 338323
UniGene Hs.449637
RefSeq NM_176822 XM_006718218
HUGO HGNC:22939
OMIM 609665
CCDS CCDS7776
HPRD
IMGT
EMBL AY154469 BK001107
GenPept AAO18165 DAA01240
RNA Seq Atlas 338323