|
InnateDB Gene
|
IDBG-300386.4
|
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
|
Gene Symbol
|
PTENP1
|
|
Gene Name
|
phosphatase and tensin homolog pseudogene 1
|
|
Synonyms
|
psiPTEN; PTEN-rs; PTEN2; PTENpg1; PTH2
|
|
Species
|
Homo sapiens
|
|
Ensembl Gene
|
ENSG00000237984
|
|
Encoded Proteins
|
|
|
Protein Structure
|
|
|
Useful resources
|
Stemformatics
EHFPI
ImmGen
|
| Summary |
PTENP1 is a highly homologous processed pseudogene of the tumor suppressor gene PTEN (MIM 601728) that itself exerts a tumor suppressive function by acting as a decoy for PTEN-targeting miRNAs (Poliseno et al., 2010 [PubMed 20577206]).[supplied by OMIM, Nov 2010]
The phosphatase and tensin homolog (PTEN) gene encodes a tumor suppressor that functions by negatively regulating the AKT/PKB signaling pathway. A highly homologous processed pseudogene of PTEN is found on chromosome 9 and regulates PTEN by both sense and antisense RNAs (Gene ID: 101243555). This long-noncoding RNA (lncRNA) acts as a decoy for PTEN targeting microRNAs and also exerts a tumor suppressive activity. [provided by RefSeq, Apr 2013]
|
| Type |
transcribed_processed_pseudogene
|
|
Genomic Location
|
Chromosome 9:33673504-33677499
|
|
Strand
|
Reverse strand
|
|
Band
|
p13.3
|
|
Transcripts
|
|
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
|
|
|
No orthologs found for this gene |
|
SwissProt
|
|
|
TrEMBL
|
|
|
UniProt Splice Variant
|
|
|
Entrez Gene
|
|
|
UniGene
|
Hs.493716
|
|
RefSeq
|
|
|
HUGO
|
|
|
OMIM
|
|
|
CCDS
|
|
| HPRD |
|
|
IMGT
|
|
|
EMBL
|
|
|
GenPept
|
|
|
RNA Seq Atlas
|
|
|
|
|
Version 5.4