InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: HLA-DQB2

Summary

InnateDB Gene

IDBG-303869.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

HLA-DQB2

Gene Name

major histocompatibility complex, class II, DQ beta 2

Synonyms

HLA-DQB1; HLA-DXB

Species

Homo sapiens

Ensembl Gene

ENSG00000232629

Encoded Proteins

IDBP-374618

major histocompatibility complex, class II, DQ beta 2

IDBP-374622

major histocompatibility complex, class II, DQ beta 2

IDBP-374624

major histocompatibility complex, class II, DQ beta 2

IDBP-374627

major histocompatibility complex, class II, DQ beta 2

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

HLA-DQB2 belongs to the family of HLA class II beta chain paralogs. Class II molecules are heterodimers consisting of an alpha (DQA) and a beta chain (DQB), both anchored in the membrane. They play a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). Polymorphisms in the alpha and beta chains specify the peptide binding specificity, and typing for these polymorphisms is routinely done for bone marrow transplantation. However this gene, HLA-DQB2, is not routinely typed, as it is not thought to have an effect on transplantation. There is conflicting evidence in the literature and public sequence databases for the protein-coding capacity of HLA-DQB2. Because there is evidence of transcription and an intact ORF, HLA-DQB2 is represented in Entrez Gene and in RefSeq as a protein-coding locus. [provided by RefSeq, Oct 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 6:32756098-32763534

Strand

Reverse strand

Band

p21.32

Transcripts

ENST00000437316	ENSP00000396330
ENST00000411527	ENSP00000390431
ENST00000427449	ENSP00000415997
ENST00000435145	ENSP00000410512

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0032395	MHC class II receptor activity

Biological Process

GO:0002504	antigen processing and presentation of peptide or polysaccharide antigen via MHC class II
GO:0006955	immune response
GO:0019221	cytokine-mediated signaling pathway
GO:0019882	antigen processing and presentation
GO:0019886	antigen processing and presentation of exogenous peptide antigen via MHC class II
GO:0031295	T cell costimulation
GO:0050852	T cell receptor signaling pathway
GO:0060333	interferon-gamma-mediated signaling pathway

Cellular Component

GO:0000139	Golgi membrane
GO:0005765	lysosomal membrane
GO:0005886	plasma membrane
GO:0010008	endosome membrane
GO:0012507	ER to Golgi transport vesicle membrane
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0030658	transport vesicle membrane
GO:0030666	endocytic vesicle membrane
GO:0030669	clathrin-coated endocytic vesicle membrane
GO:0032588	trans-Golgi network membrane
GO:0042613	MHC class II protein complex
GO:0071556	integral component of lumenal side of endoplasmic reticulum membrane