|
InnateDB Gene
|
IDBG-304387.4
|
|
Last Modified
|
2014-10-13 [Report errors or provide feedback]
|
|
Gene Symbol
|
XIST
|
|
Gene Name
|
X (inactive)-specific transcript (non-protein coding)
|
|
Synonyms
|
DXS1089; DXS399E; LINC00001; NCRNA00001; swd66; SXI1
|
|
Species
|
Homo sapiens
|
|
Ensembl Gene
|
ENSG00000229807
|
|
Encoded Proteins
|
|
|
Protein Structure
|
|
|
Useful resources
|
Stemformatics
EHFPI
ImmGen
|
| Summary |
X inactivation is an early developmental process in mammalian females that transcriptionally silences one of the pair of X chromosomes, thus providing dosage equivalence between males and females. The process is regulated by several factors, including a region of chromosome X called the X inactivation center (XIC). The XIC comprises several non-coding and protein-coding genes, and this gene was the first non-coding gene identified within the XIC. This gene is expressed exclusively from the XIC of the inactive X chromosome, and is essential for the initiation and spread of X-inactivation. The transcript is a spliced RNA. Alternatively spliced transcript variants have been identified, but their full length sequences have not been determined. Mutations in the XIST promoter cause familial skewed X inactivation. [provided by RefSeq, Apr 2012]
|
| Type |
lincRNA
|
|
Genomic Location
|
Chromosome X:73820651-73852753
|
|
Strand
|
Reverse strand
|
|
Band
|
q13.2
|
|
Transcripts
|
|
|
Number of Interactions
|
This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
| Experimentally validated |
| Total |
3
[view]
|
| Protein-Protein |
3
[view]
|
| Protein-DNA |
0
|
| Protein-RNA |
0
|
| DNA-DNA |
0
|
| RNA-RNA |
0
|
| DNA-RNA |
0
|
|
|
|
|
|
No orthologs found for this gene |
|
SwissProt
|
|
|
TrEMBL
|
|
|
UniProt Splice Variant
|
|
|
Entrez Gene
|
|
|
UniGene
|
Hs.529901
Hs.630553
Hs.655450
Hs.721880
|
|
RefSeq
|
|
|
HUGO
|
|
|
OMIM
|
|
|
CCDS
|
|
| HPRD |
|
|
IMGT
|
|
|
EMBL
|
|
|
GenPept
|
|
|
RNA Seq Atlas
|
|
|
|
|
Version 5.4