Version 5.4
Homo sapiens Gene: SCO1
Summary
InnateDB Gene IDBG-30643.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SCO1
Gene Name SCO1 cytochrome c oxidase assembly protein
Synonyms SCOD1
Species Homo sapiens
Ensembl Gene ENSG00000133028
Encoded Proteins
IDBP-30645
SCO cytochrome oxidase deficient homolog 1 (yeast)
IDBP-764253
IDBP-764397
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Mammalian cytochrome c oxidase (COX) catalyzes the transfer of reducing equivalents from cytochrome c to molecular oxygen and pumps protons across the inner mitochondrial membrane. In yeast, 2 related COX assembly genes, SCO1 and SCO2 (synthesis of cytochrome c oxidase), enable subunits 1 and 2 to be incorporated into the holoprotein. This gene is the human homolog to the yeast SCO1 gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:10672474-10698375
Strand Reverse strand
Band p13.1
Transcripts
ENST00000255390 ENSP00000255390
ENST00000577335 ENSP00000464032
ENST00000579396
ENST00000577427 ENSP00000463387
ENST00000582053
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
Experimentally validated
Total 6 [view]
Protein-Protein 3 [view]
Protein-DNA 3 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005507 copper ion binding
GO:0016209 antioxidant activity
GO:0016491 oxidoreductase activity
Biological Process
GO:0006091 generation of precursor metabolites and energy
GO:0006825 copper ion transport
GO:0006878 cellular copper ion homeostasis
GO:0008535 respiratory chain complex IV assembly
GO:0055114 oxidation-reduction process
Cellular Component
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane
GO:0030016 myofibril
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000069844
View Gene Order
ENSBTAG00000021780
Not yet available
Pathways
NETPATH
REACTOME
REACT_22393
Respiratory electron transport pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_6305
Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. pathway
REACT_267716
Orphan transporters pathway
REACT_111083
The citric acid (TCA) cycle and respiratory electron transport pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt O75880
TrEMBL J3QL56 J3QR42
UniProt Splice Variant
Entrez Gene 6341
UniGene Hs.14511
RefSeq NM_004589 XM_005256751
HUGO HGNC:10603
OMIM 603644
CCDS CCDS11158
HPRD
IMGT
EMBL AC002347 AF026852 AF131816 AF183424 AF295381 AF295382 AF295383 AF295384 AF295385 AF295386 AK315595 BC015504 CH471108
GenPept AAD08641 AAD20051 AAG09693 AAG23836 AAH15504 BAG37967 EAW89997
RNA Seq Atlas 6341

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca