InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: NTF4

Summary

InnateDB Gene

IDBG-307463.4

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

NTF4

Gene Name

neurotrophin 4

Synonyms

GLC10; GLC1O; NT-4; NT-4/5; NT-5; NT4; NT5; NTF5

Species

Homo sapiens

Ensembl Gene

ENSG00000225950

Encoded Proteins

IDBP-761906

IDBP-762259

IDBP-759918

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

Entrez Gene

Summary

This gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NTF5-deficient mice only show minor cellular deficits and develop normally to adulthood. [provided by RefSeq, Jul 2008]
This gene is a member of a family of neurotrophic factors, neurotrophins, that control survival and differentiation of mammalian neurons. The expression of this gene is ubiquitous and less influenced by environmental signals. While knock-outs of other neurotrophins including nerve growth factor, brain-derived neurotrophic factor, and neurotrophin 3 prove lethal during early postnatal development, NTF5-deficient mice only show minor cellular deficits and develop normally to adulthood. [provided by RefSeq, Jul 2008]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 19:49055793-49065076

Strand

Reverse strand

Band

q13.33

Transcripts

ENST00000599795	ENSP00000470689
ENST00000595857	ENSP00000471508
ENST00000594938
ENST00000593537	ENSP00000469455

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005102	receptor binding
GO:0008083	growth factor activity

Biological Process

GO:0007402	ganglion mother cell fate determination
GO:0007616	long-term memory
GO:0008052	sensory organ boundary specification
GO:0008344	adult locomotory behavior
GO:0008544	epidermis development
GO:0042490	mechanoreceptor differentiation
GO:0060384	innervation
GO:0060548	negative regulation of cell death
GO:0061193	taste bud development

Cellular Component

GO:0005576	extracellular region
GO:0005788	endoplasmic reticulum lumen

Orthologs

No orthologs found for this gene

Pathways

NETPATH

REACTOME

KEGG

hsa04010

MAPK signaling pathway pathway

hsa04722

Neurotrophin signaling pathway pathway

INOH

INOH website

GPCR signaling pathway

PID NCI

trkrpathway

Neurotrophic factor-mediated Trk receptor signaling

p75ntrpathway

p75(NTR)-mediated signaling

Cross-References

SwissProt

P34130

TrEMBL

A0A024QZE4 M0QZQ0 M0R0X2

UniProt Splice Variant

Entrez Gene

4909

UniGene

Hs.266902 Hs.598703 Hs.743915

RefSeq

NM_006179 XM_005258962 XM_006723232

HUGO

HGNC:8024

OMIM

162662

CCDS

CCDS12754

HPRD

IMGT

EMBL

AC008687 BC012421 BT019368 BT019369 CH471177 CR541900 M86528

GenPept

AAA60154 AAH12421 AAV38175 AAV38176 CAG46698 EAW52441 EAW52442 EAW52443

RNA Seq Atlas

4909