Version 5.4
Homo sapiens Gene: SALL1
Summary
InnateDB Gene IDBG-30748.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SALL1
Gene Name sal-like 1 (Drosophila)
Synonyms HEL-S-89; HSAL1; Sal-1; TBS; ZNF794
Species Homo sapiens
Ensembl Gene ENSG00000103449
Encoded Proteins
IDBP-30750
sal-like 1 (Drosophila)
IDBP-376888
sal-like 1 (Drosophila)
IDBP-752212
IDBP-752585
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a zinc finger transcriptional repressor and may be part of the NuRD histone deacetylase complex (HDAC). Defects in this gene are a cause of Townes-Brocks syndrome (TBS) as well as bronchio-oto-renal syndrome (BOR). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:51135975-51151367
Strand Reverse strand
Band q12.1
Transcripts
ENST00000251020 ENSP00000251020
ENST00000440970 ENSP00000407914
ENST00000562674
ENST00000570206 ENSP00000456777
ENST00000566102 ENSP00000455582
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 9 interaction(s) predicted by orthology.
Experimentally validated
Total 6 [view]
Protein-Protein 6 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 9 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
GO:0003682 chromatin binding
GO:0003700 sequence-specific DNA binding transcription factor activity
GO:0004407 histone deacetylase activity
GO:0005515 protein binding
GO:0008013 beta-catenin binding
GO:0046872 metal ion binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001657 ureteric bud development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001822 kidney development
GO:0001843 neural tube closure
GO:0003281 ventricular septum development
GO:0003337 mesenchymal to epithelial transition involved in metanephros morphogenesis
GO:0006351 transcription, DNA-templated
GO:0007507 heart development
GO:0008406 gonad development
GO:0016575 histone deacetylation
GO:0021553 olfactory nerve development
GO:0021772 olfactory bulb development
GO:0021889 olfactory bulb interneuron differentiation
GO:0021915 neural tube development
GO:0021983 pituitary gland development
GO:0030177 positive regulation of Wnt signaling pathway
GO:0030325 adrenal gland development
GO:0031129 inductive cell-cell signaling
GO:0035136 forelimb morphogenesis
GO:0035137 hindlimb morphogenesis
GO:0042473 outer ear morphogenesis
GO:0042733 embryonic digit morphogenesis
GO:0045666 positive regulation of neuron differentiation
GO:0045879 negative regulation of smoothened signaling pathway
GO:0045892 negative regulation of transcription, DNA-templated
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0048566 embryonic digestive tract development
GO:0060173 limb development
GO:0061034 olfactory bulb mitral cell layer development
GO:0072073 kidney epithelium development
GO:0072092 ureteric bud invasion
GO:2000177 regulation of neural precursor cell proliferation
Cellular Component
GO:0000792 heterochromatin
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0010369 chromocenter
GO:0016581 NuRD complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000031665
View Gene Order
ENSBTAG00000008544
Not yet available
Cross-References
SwissProt
TrEMBL H3BQ32
UniProt Splice Variant
Entrez Gene 6299
UniGene Hs.135787
RefSeq NM_001127892 NM_002968 XM_006721241
HUGO HGNC:10524
OMIM 602218
CCDS CCDS10747 CCDS45483
HPRD 03742
IMGT
EMBL AC009166
GenPept
RNA Seq Atlas 6299

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca