Version 5.4
Homo sapiens Gene: POLR2J2
Summary
InnateDB Gene IDBG-307939.5
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol POLR2J2
Gene Name DNA-directed RNA polymerase II subunit RPB11-b1
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000228049
Encoded Proteins
IDBP-13926
polymerase (RNA) II (DNA directed) polypeptide J2
IDBP-33872
polymerase (RNA) II (DNA directed) polypeptide J2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is a member of the RNA polymerase II subunit 11 gene family, which includes three genes in a cluster on chromosome 7q22.1 and a pseudogene on chromosome 7p13. The founding member of this family, DNA directed RNA polymerase II polypeptide J, has been shown to encode a subunit of RNA polymerase II, the polymerase responsible for synthesizing messenger RNA in eukaryotes. This locus produces multiple, alternatively spliced transcripts that potentially express isoforms with distinct C-termini compared to DNA directed RNA polymerase II polypeptide J. Most or all variants are spliced to include additional non-coding exons at the 3' end which makes them candidates for nonsense-mediated decay (NMD). Consequently, it is not known if this locus expresses a protein or proteins in vivo. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:102666079-102671629
Strand Reverse strand
Band q22.1
Transcripts
ENST00000333432 ENSP00000330898
ENST00000358438 ENSP00000351218
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0001055 RNA polymerase II activity
GO:0003677 DNA binding
GO:0046983 protein dimerization activity
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006366 transcription from RNA polymerase II promoter
Cellular Component
GO:0005665 DNA-directed RNA polymerase II, core complex
Orthologs
No orthologs found for this gene
Cross-References
SwissProt
TrEMBL A6NFM0
UniProt Splice Variant
Entrez Gene
UniGene Hs.610255
RefSeq NM_032959
HUGO HGNC:23208
OMIM
CCDS CCDS43627
HPRD 17878
IMGT
EMBL AC105052
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca