Version 5.4
Homo sapiens Gene: METAP1
Summary
InnateDB Gene IDBG-31018.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol METAP1
Gene Name methionyl aminopeptidase 1
Synonyms MAP1A; MetAP1A
Species Homo sapiens
Ensembl Gene ENSG00000164024
Encoded Proteins
IDBP-31020
methionyl aminopeptidase 1
IDBP-482816
methionyl aminopeptidase 1
IDBP-482958
methionyl aminopeptidase 1
IDBP-481359
methionyl aminopeptidase 1
IDBP-484673
methionyl aminopeptidase 1
IDBP-481685
methionyl aminopeptidase 1
IDBP-483566
methionyl aminopeptidase 1
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 4:98995620-99062813
Strand Forward strand
Band q23
Transcripts
ENST00000296411 ENSP00000296411
ENST00000510209
ENST00000507537 ENSP00000427563
ENST00000506238 ENSP00000426702
ENST00000503247 ENSP00000424462
ENST00000510107 ENSP00000427187
ENST00000513199
ENST00000506548
ENST00000513097
ENST00000510133 ENSP00000423071
ENST00000514051 ENSP00000422689
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
Experimentally validated
Total 7 [view]
Protein-Protein 7 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0004177 aminopeptidase activity
GO:0008235 metalloexopeptidase activity
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006417 regulation of translation
GO:0006508 proteolysis
GO:0007603 phototransduction, visible light
GO:0008152 metabolic process
GO:0016056 rhodopsin mediated signaling pathway
GO:0018206 peptidyl-methionine modification
GO:0022400 regulation of rhodopsin mediated signaling pathway
GO:0031365 N-terminal protein amino acid modification
GO:0070084 protein initiator methionine removal
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0022626 cytosolic ribosome
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005813
View Gene Order
ENSBTAG00000016004
Not yet available
Pathways
NETPATH
REACTOME
REACT_111102
Signal Transduction pathway
REACT_160102
Diseases associated with visual transduction pathway
REACT_160125
Visual phototransduction pathway
REACT_163722
The phototransduction cascade pathway
REACT_163919
Inactivation, recovery and regulation of the phototransduction cascade pathway
REACT_116125
Disease pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.606400
RefSeq NM_015143 XM_005262867
HUGO
OMIM
CCDS CCDS47110
HPRD 10071
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca