Version 5.4
Homo sapiens Gene: GRHL2
Summary
InnateDB Gene IDBG-31029.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol GRHL2
Gene Name grainyhead-like 2 (Drosophila)
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000083307
Encoded Proteins
IDBP-31031
grainyhead-like 2 (Drosophila)
IDBP-238543
grainyhead-like 2 (Drosophila)
IDBP-473989
grainyhead-like 2 (Drosophila)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a transcription factor that can act as a homodimer or as a heterodimer with either GRHL1 or GRHL3. Defects in this gene are a cause of non-syndromic sensorineural deafness autosomal dominant type 28 (DFNA28).[provided by RefSeq, Mar 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:101492432-101669726
Strand Forward strand
Band q22.3
Transcripts
ENST00000251808 ENSP00000251808
ENST00000395927 ENSP00000379260
ENST00000521085 ENSP00000430473
ENST00000472106
ENST00000517674
ENST00000474338
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 3 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003677 DNA binding
Biological Process
GO:0001701 in utero embryonic development
GO:0001843 neural tube closure
GO:0003208 cardiac ventricle morphogenesis
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0007420 brain development
GO:0010468 regulation of gene expression
GO:0021915 neural tube development
GO:0030323 respiratory tube development
GO:0035264 multicellular organism growth
GO:0042733 embryonic digit morphogenesis
GO:0043010 camera-type eye development
GO:0048568 embryonic organ development
GO:0048701 embryonic cranial skeleton morphogenesis
GO:0060324 face development
GO:0060463 lung lobe morphogenesis
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022286
View Gene Order
ENSBTAG00000004518
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.661088
RefSeq NM_024915
HUGO
OMIM
CCDS CCDS34931
HPRD 10545
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca