Version 5.4
Homo sapiens Gene: NCALD
Summary
InnateDB Gene IDBG-31052.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol NCALD
Gene Name neurocalcin delta
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000104490
Encoded Proteins
IDBP-31054
neurocalcin delta
IDBP-31056
neurocalcin delta
IDBP-238577
neurocalcin delta
IDBP-481265
neurocalcin delta
IDBP-478974
neurocalcin delta
IDBP-484331
neurocalcin delta
IDBP-483270
neurocalcin delta
IDBP-483895
neurocalcin delta
IDBP-480314
neurocalcin delta
IDBP-481958
neurocalcin delta
IDBP-481683
neurocalcin delta
IDBP-483999
neurocalcin delta
IDBP-474495
neurocalcin delta
IDBP-473633
neurocalcin delta
IDBP-484262
neurocalcin delta
IDBP-483893
neurocalcin delta
IDBP-481659
neurocalcin delta
IDBP-475683
neurocalcin delta
IDBP-475213
neurocalcin delta
IDBP-483964
neurocalcin delta
IDBP-475741
neurocalcin delta
IDBP-477280
neurocalcin delta
IDBP-481921
neurocalcin delta
IDBP-478393
neurocalcin delta
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the neuronal calcium sensor (NCS) family of calcium-binding proteins. The protein contains an N-terminal myristoylation signal and four EF-hand calcium binding loops. The protein is cytosolic at resting calcium levels; however, elevated intracellular calcium levels induce a conformational change that exposes the myristoyl group, resulting in protein association with membranes and partial co-localization with the perinuclear trans-golgi network. The protein is thought to be a regulator of G protein-coupled receptor signal transduction. Several alternatively spliced variants of this gene have been determined, all of which encode the same protein; additional variants may exist but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 8:101686543-102124907
Strand Reverse strand
Band q22.3
Transcripts
ENST00000311028 ENSP00000310587
ENST00000220931 ENSP00000220931
ENST00000395923 ENSP00000379256
ENST00000521599 ENSP00000428105
ENST00000519508 ENSP00000430476
ENST00000522951 ENSP00000428781
ENST00000522754
ENST00000522448 ENSP00000429466
ENST00000520690 ENSP00000429255
ENST00000518727 ENSP00000430731
ENST00000520425 ENSP00000430925
ENST00000518166 ENSP00000429522
ENST00000522252 ENSP00000428598
ENST00000517822 ENSP00000428312
ENST00000524209 ENSP00000429493
ENST00000517531 ENSP00000429245
ENST00000521964 ENSP00000430064
ENST00000519098 ENSP00000430534
ENST00000523923 ENSP00000428193
ENST00000520346 ENSP00000430365
ENST00000518661 ENSP00000428093
ENST00000522206 ENSP00000429296
ENST00000524137 ENSP00000430578
ENST00000522078 ENSP00000429162
ENST00000523645 ENSP00000429347
ENST00000518952
ENST00000521957
ENST00000521371
ENST00000524101
ENST00000517639
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 7 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0003779 actin binding
GO:0005509 calcium ion binding
GO:0005515 protein binding
GO:0015631 tubulin binding
GO:0030276 clathrin binding
GO:0043014 alpha-tubulin binding
Biological Process
GO:0003073 regulation of systemic arterial blood pressure
GO:0007268 synaptic transmission
GO:0016192 vesicle-mediated transport
GO:0019722 calcium-mediated signaling
Cellular Component
GO:0005622 intracellular
GO:0005829 cytosol
GO:0030130 clathrin coat of trans-Golgi network vesicle
GO:0070062 extracellular vesicular exosome
Orthologs
No orthologs found for this gene
Pathways
NETPATH
REACTOME
REACT_13685
Neuronal System pathway
REACT_21322
Ionotropic activity of Kainate Receptors pathway
REACT_21312
Activation of Kainate Receptors upon glutamate binding pathway
REACT_13477
Transmission across Chemical Synapses pathway
REACT_21346
Activation of Ca-permeable Kainate Receptor pathway
REACT_15370
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.492427
RefSeq NM_001040624 NM_001040625 NM_001040626 NM_001040627 NM_001040628 NM_001040629 NM_001040630 NM_032041 XM_006716672
HUGO
OMIM
CCDS CCDS6292
HPRD 09466
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca