Version 5.4
Homo sapiens Gene: MYOCD
Summary
InnateDB Gene IDBG-31095.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MYOCD
Gene Name myocardin
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000141052
Encoded Proteins
IDBP-31099
myocardin
IDBP-369073
myocardin
IDBP-369087
myocardin
IDBP-762577
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a nuclear protein, which is expressed in heart, aorta, and in smooth muscle cell-containing tissues. It functions as a transcriptional co-activator of serum response factor (SRF) and modulates expression of cardiac and smooth muscle-specific SRF-target genes, and thus may play a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:12665890-12768949
Strand Forward strand
Band p12
Transcripts
ENST00000343344 ENSP00000341835
ENST00000395988
ENST00000425538 ENSP00000401678
ENST00000443061 ENSP00000400148
ENST00000579237 ENSP00000462694
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 20 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 20 [view]
Protein-Protein 19 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 1 [view]
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0001046 core promoter sequence-specific DNA binding
GO:0001076 RNA polymerase II transcription factor binding transcription factor activity
GO:0001077 RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription
GO:0003676 nucleic acid binding
GO:0003713 transcription coactivator activity
GO:0005515 protein binding
GO:0008134 transcription factor binding
GO:0019904 protein domain specific binding
GO:0035035 histone acetyltransferase binding
GO:0042826 histone deacetylase binding
GO:0070412 R-SMAD binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001560 regulation of cell growth by extracellular stimulus
GO:0001570 vasculogenesis
GO:0001666 response to hypoxia
GO:0003231 cardiac ventricle development
GO:0003257 positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0006366 transcription from RNA polymerase II promoter
GO:0007507 heart development
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0010667 negative regulation of cardiac muscle cell apoptotic process
GO:0010832 negative regulation of myotube differentiation
GO:0030511 positive regulation of transforming growth factor beta receptor signaling pathway
GO:0035051 cardiac cell differentiation
GO:0035065 regulation of histone acetylation
GO:0035733 hepatic stellate cell activation
GO:0042692 muscle cell differentiation
GO:0043388 positive regulation of DNA binding
GO:0043954 cellular component maintenance
GO:0045661 regulation of myoblast differentiation
GO:0045736 negative regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0045987 positive regulation of smooth muscle contraction
GO:0048286 lung alveolus development
GO:0048565 digestive tract development
GO:0051091 positive regulation of sequence-specific DNA binding transcription factor activity
GO:0051145 smooth muscle cell differentiation
GO:0051150 regulation of smooth muscle cell differentiation
GO:0051152 positive regulation of smooth muscle cell differentiation
GO:0055007 cardiac muscle cell differentiation
GO:0055012 ventricular cardiac muscle cell differentiation
GO:0060065 uterus development
GO:0060157 urinary bladder development
GO:0061049 cell growth involved in cardiac muscle cell development
GO:0071363 cellular response to growth factor stimulus
GO:0071456 cellular response to hypoxia
GO:0097070 ductus arteriosus closure
GO:1900222 negative regulation of beta-amyloid clearance
GO:2000721 positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation
GO:2000724 positive regulation of cardiac vascular smooth muscle cell differentiation
GO:2000727 positive regulation of cardiac muscle cell differentiation
GO:2001015 negative regulation of skeletal muscle cell differentiation
GO:2001141 regulation of RNA biosynthetic process
Cellular Component
GO:0005634 nucleus
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000020542
View Gene Order
ENSBTAG00000035706
Not yet available
Pathways
NETPATH
REACTOME
KEGG
INOH
PID NCI
pdgfrbpathway
PDGFR-beta signaling pathway
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.462257 Hs.567641 Hs.608235 Hs.614281
RefSeq NM_001146312 NM_153604 XM_005256864
HUGO
OMIM
CCDS CCDS11163 CCDS54091
HPRD 09362
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca