Version 5.4
Homo sapiens Gene: CES5A
Summary
InnateDB Gene IDBG-31642.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CES5A
Gene Name carboxylesterase 5A
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000159398
Encoded Proteins
IDBP-31644
carboxylesterase 5A
IDBP-31646
carboxylesterase 5A
IDBP-482320
carboxylesterase 5A
IDBP-754226
IDBP-480332
carboxylesterase 5A
IDBP-475497
carboxylesterase 5A
IDBP-745945
IDBP-601939
carboxylesterase 5A
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They also participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene, also called CES5, is predominantly expressed in peripheral tissues, including brain, kidney, lung and testis. It encodes a secreted enzyme. Because of high levels in the urine of male domestic cats, this enzyme is also called cauxin (carboxylesterase-like urinary excreted protein). The enzyme functions in regulating the production of a pheromone precursor and may contribute to lipid and cholesterol transfer processes within male reproductive fluids. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 16:55846154-55956031
Strand Reverse strand
Band q12.2
Transcripts
ENST00000319165 ENSP00000324271
ENST00000290567 ENSP00000290567
ENST00000521992 ENSP00000428864
ENST00000521228 ENSP00000461804
ENST00000518005 ENSP00000428571
ENST00000520435 ENSP00000428887
ENST00000541580
ENST00000544479 ENSP00000461117
ENST00000536025 ENSP00000439810
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0016787 hydrolase activity
GO:0052689 carboxylic ester hydrolase activity
Biological Process
GO:0008152 metabolic process
Cellular Component
GO:0005576 extracellular region
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000058019
View Gene Order
ENSBTAG00000011164
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.350800
RefSeq NM_001143685 NM_001190158 NM_145024 XM_005255841 XM_005276868
HUGO
OMIM
CCDS CCDS10755 CCDS45490 CCDS54012
HPRD 07016
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca