Version 5.4
Homo sapiens Gene: CTR9
Summary
InnateDB Gene IDBG-31890.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CTR9
Gene Name Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
Synonyms p150; p150TSP; SH2BP1; TSBP
Species Homo sapiens
Ensembl Gene ENSG00000198730
Encoded Proteins
IDBP-31894
Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
IDBP-596017
Ctr9, Paf1/RNA polymerase II complex component, homolog (S. cerevisiae)
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary CTR9, parafibromin (CDC73; MIM 607393), LEO1 (MIM 610507), and PAF1 (MIM 610506) form the PAF protein complex, which associates with the RNA polymerase II subunit POLR2A (MIM 180660) and with a histone methyltransferase complex (Rozenblatt-Rosen et al., 2005 [PubMed 15632063]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 11:10750987-10779743
Strand Forward strand
Band p15.4
Transcripts
ENST00000361367 ENSP00000355013
ENST00000524523 ENSP00000431458
ENST00000526874
ENST00000529355
ENST00000529898
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 42 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 42 [view]
Protein-Protein 40 [view]
Protein-DNA 2 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042169 SH2 domain binding
Biological Process
GO:0000122 negative regulation of transcription from RNA polymerase II promoter
GO:0001711 endodermal cell fate commitment
GO:0006351 transcription, DNA-templated
GO:0007259 JAK-STAT cascade
GO:0010390 histone monoubiquitination
GO:0016055 Wnt signaling pathway
GO:0019827 stem cell maintenance
GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter
GO:0033523 histone H2B ubiquitination
GO:0045638 negative regulation of myeloid cell differentiation
GO:0045944 positive regulation of transcription from RNA polymerase II promoter
GO:0051571 positive regulation of histone H3-K4 methylation
GO:0070102 interleukin-6-mediated signaling pathway
GO:0071222 cellular response to lipopolysaccharide
GO:0080182 histone H3-K4 trimethylation
GO:2001162 positive regulation of histone H3-K79 methylation
Cellular Component
GO:0005634 nucleus
GO:0016593 Cdc73/Paf1 complex
GO:0016607 nuclear speck
GO:0035327 transcriptionally active chromatin
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000005609
View Gene Order
ENSBTAG00000015566
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.614410 Hs.725151
RefSeq NM_014633
HUGO
OMIM
CCDS CCDS7805
HPRD 06717
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca