Version 5.4
Homo sapiens Gene: MAP4
Summary
InnateDB Gene IDBG-32054.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol MAP4
Gene Name microtubule-associated protein 4
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000047849
Encoded Proteins
IDBP-32056
microtubule-associated protein 4
IDBP-32060
microtubule-associated protein 4
IDBP-32064
microtubule-associated protein 4
IDBP-238948
microtubule-associated protein 4
IDBP-375561
microtubule-associated protein 4
IDBP-375565
microtubule-associated protein 4
IDBP-375567
microtubule-associated protein 4
IDBP-375596
microtubule-associated protein 4
IDBP-375602
microtubule-associated protein 4
IDBP-375608
microtubule-associated protein 4
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a major non-neuronal microtubule-associated protein. This protein contains a domain similar to the microtubule-binding domains of neuronal microtubule-associated protein (MAP2) and microtubule-associated protein tau (MAPT/TAU). This protein promotes microtubule assembly, and has been shown to counteract destabilization of interphase microtubule catastrophe promotion. Cyclin B was found to interact with this protein, which targets cell division cycle 2 (CDC2) kinase to microtubules. The phosphorylation of this protein affects microtubule properties and cell cycle progression. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 3:47850690-48089272
Strand Reverse strand
Band p21.31
Transcripts
ENST00000360240 ENSP00000353375
ENST00000335271 ENSP00000334770
ENST00000383736 ENSP00000373242
ENST00000395734 ENSP00000379083
ENST00000429422 ENSP00000416743
ENST00000426837 ENSP00000407602
ENST00000420772 ENSP00000409731
ENST00000423088 ENSP00000415689
ENST00000434267 ENSP00000402767
ENST00000439356 ENSP00000397414
ENST00000477765
ENST00000462206
ENST00000497735
ENST00000482752
ENST00000468075
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 52 experimentally validated interaction(s) in this database.
They are also associated with 4 interaction(s) predicted by orthology.
Experimentally validated
Total 52 [view]
Protein-Protein 51 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 4 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005198 structural molecule activity
GO:0005515 protein binding
GO:0008017 microtubule binding
GO:0015631 tubulin binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0007052 mitotic spindle organization
GO:0051012 microtubule sliding
GO:0051294 establishment of spindle orientation
GO:0051301 cell division
Cellular Component
GO:0005737 cytoplasm
GO:0005874 microtubule
GO:0005875 microtubule associated complex
GO:0005886 plasma membrane
GO:0015630 microtubule cytoskeleton
GO:0070062 extracellular vesicular exosome
GO:0072686 mitotic spindle
Orthologs
Species
Mus musculus
Gene ID
Gene Order
ENSMUSG00000032479
View Gene Order
Cross-References
SwissProt
TrEMBL B5MEG9
UniProt Splice Variant
Entrez Gene 4134
UniGene Hs.517949 Hs.603055
RefSeq NM_001134364 NM_002375 NM_030885 XM_006713145 XM_006713160
HUGO HGNC:6862
OMIM 157132
CCDS CCDS33750 CCDS46818 CCDS46821
HPRD 01141
IMGT
EMBL AC124916 AC139667
GenPept
RNA Seq Atlas 4134

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca