InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Gene: IL25

Summary

InnateDB Gene

IDBG-3218.5

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

IL25

Gene Name

interleukin 25

Synonyms

Species

Homo sapiens

Ensembl Gene

ENSG00000166090

Encoded Proteins

IDBP-3220

interleukin 25

IDBP-235797

interleukin 25

Protein Structure

Useful resources

Stemformatics EHFPI ImmGen

InnateDB Annotation

Summary

PMID 20200520

IL25, a member of the IL17 cytokine family, promotes the accumulation of a lineage-negative multipotent progenitor (MPP) cell population in the gut-associated lymphoid tissue that promotes T(H)2 cytokine responses, presenting an innate immune pathway that promotes T(H)2 cytokine responses at mucosal sites.

InnateDB Annotation from Orthologs

Summary

PMID 24631157

[Mus musculus] Chitin induces IL25, IL33, and TSLP which are required to stimulate ILC2 production of IL5 and IL13. IL5 and IL13, in turn, are required for the accumulation of eosinophils and alternatively activated macrophages that are associated with allergy.

PMID 26847546

[Mus musculus] Tuft cells express Il25 and elicit group 2 innate lymphoid cells in a Trpm5-dependent manner in response to parasite colonization.

Entrez Gene

Summary

The protein encoded by this gene is a cytokine that shares sequence similarity with interleukin 17. This cytokine can induce NF-kappaB activation, and stimulate the production of interleukin 8. Both this cytokine and interleukin 17B are ligands for the cytokine receptor IL17BR. Studies of a similar gene in mice suggest that this cytokine may be a pro-inflammatory cytokine favoring the Th2-type immune response. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]

Gene Information

Type

Protein coding

Genomic Location

Chromosome 14:23372809-23376403

Strand

Forward strand

Band

q11.2

Transcripts

ENST00000329715	ENSP00000328111
ENST00000397242	ENSP00000380417

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	4 [view]
Protein-Protein	4 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005125	cytokine activity
GO:0030380	interleukin-17E receptor binding

Biological Process

GO:0002437	inflammatory response to antigenic stimulus
GO:0006954	inflammatory response
GO:0008150	biological_process
GO:0009620	response to fungus
GO:0009624	response to nematode
GO:0030222	eosinophil differentiation
GO:0045087	innate immune response (InnateDB)
GO:0045944	positive regulation of transcription from RNA polymerase II promoter

Cellular Component

GO:0005576	extracellular region
GO:0005615	extracellular space

Orthologs

Species

Mus musculus

Bos taurus

Gene ID

Gene Order

ENSMUSG00000040770

View Gene Order

ENSBTAG00000009701

Not yet available

Pathways

NETPATH

REACTOME

KEGG

hsa04060

Cytokine-cytokine receptor interaction pathway

INOH

PID NCI

Cross-References

SwissProt

Q9H293

TrEMBL

UniProt Splice Variant

Entrez Gene

64806

UniGene

Hs.302036

RefSeq

NM_022789 NM_172314

HUGO

HGNC:13765

OMIM

605658

CCDS

CCDS45086 CCDS9597

HPRD

IMGT

EMBL

AF305200 AF458059 AF461739 AY359127 BC069565 BC104929 BC104931 CH471078

GenPept

AAG40848 AAH69565 AAI04930 AAI04932 AAL57622 AAN39038 AAQ89484 EAW66162

RNA Seq Atlas

64806