Version 5.4
Homo sapiens Gene: CISD2
Summary
InnateDB Gene IDBG-32295.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol CISD2
Gene Name CDGSH iron sulfur domain 2
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000145354
Encoded Proteins
IDBP-32297
CDGSH iron sulfur domain 2
IDBP-474432
CDGSH iron sulfur domain 2
IDBP-712958
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary The protein encoded by this gene is a zinc finger protein that localizes to the endoplasmic reticulum. The encoded protein binds an iron/sulfur cluster and may be involved in calcium homeostasis. Defects in this gene are a cause of Wolfram syndrome 2. [provided by RefSeq, Mar 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 4:102868978-102889242
Strand Forward strand
Band q24
Transcripts
ENST00000273986 ENSP00000273986
ENST00000503643 ENSP00000423716
ENST00000574446 ENSP00000458976
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
Experimentally validated
Total 5 [view]
Protein-Protein 5 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
GO:0044822 poly(A) RNA binding
GO:0046872 metal ion binding
GO:0051537 2 iron, 2 sulfur cluster binding
Biological Process
GO:0000422 mitochondrion degradation
GO:0010259 multicellular organismal aging
GO:0010506 regulation of autophagy
Cellular Component
GO:0005741 mitochondrial outer membrane
GO:0005783 endoplasmic reticulum
GO:0005789 endoplasmic reticulum membrane
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0043231 intracellular membrane-bounded organelle
GO:0043234 protein complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000028165
View Gene Order
ENSBTAG00000027630
Not yet available
Cross-References
SwissProt
TrEMBL I3L1N9
UniProt Splice Variant
Entrez Gene 493856
UniGene
RefSeq NM_001008388 XM_005263040
HUGO HGNC:24212
OMIM 611507
CCDS CCDS34040
HPRD 17413
IMGT
EMBL AC018797
GenPept
RNA Seq Atlas 493856

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca