Version 5.4
Homo sapiens Gene: SLC11A2
Summary
InnateDB Gene IDBG-32924.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SLC11A2
Gene Name solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
Synonyms DCT1; DMT1; NRAMP2
Species Homo sapiens
Ensembl Gene ENSG00000110911
Encoded Proteins
IDBP-32926
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
IDBP-32928
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
IDBP-240614
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
IDBP-593575
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
IDBP-593136
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
IDBP-600146
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
IDBP-588042
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
IDBP-586164
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
IDBP-583759
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
IDBP-596659
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
IDBP-591646
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
IDBP-598866
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
IDBP-601310
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
IDBP-595737
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
IDBP-596259
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
IDBP-601821
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
IDBP-584927
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
IDBP-597044
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
IDBP-588552
solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010]
Gene Information
Type Protein coding
Genomic Location Chromosome 12:50979401-51028566
Strand Reverse strand
Band q13.12
Transcripts
ENST00000262051 ENSP00000262051
ENST00000262052 ENSP00000262052
ENST00000394904 ENSP00000378364
ENST00000551215 ENSP00000450227
ENST00000546636 ENSP00000449008
ENST00000547198 ENSP00000446769
ENST00000550782
ENST00000547688 ENSP00000449200
ENST00000541174 ENSP00000444542
ENST00000545993 ENSP00000442810
ENST00000546743 ENSP00000446914
ENST00000548554
ENST00000551231
ENST00000550061
ENST00000547510 ENSP00000446653
ENST00000546488 ENSP00000450389
ENST00000547579 ENSP00000447482
ENST00000550714 ENSP00000446984
ENST00000547732 ENSP00000447102
ENST00000549110 ENSP00000447334
ENST00000548193 ENSP00000449209
ENST00000549625 ENSP00000448501
ENST00000549193
ENST00000550995
ENST00000550329
ENST00000548150 ENSP00000448273
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.
Experimentally validated
Total 8 [view]
Protein-Protein 8 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005215 transporter activity
GO:0005375 copper ion transmembrane transporter activity
GO:0005381 iron ion transmembrane transporter activity
GO:0005384 manganese ion transmembrane transporter activity
GO:0005385 zinc ion transmembrane transporter activity
GO:0005506 iron ion binding
GO:0005507 copper ion binding
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0015078 hydrogen ion transmembrane transporter activity
GO:0015086 cadmium ion transmembrane transporter activity
GO:0015087 cobalt ion transmembrane transporter activity
GO:0015093 ferrous iron transmembrane transporter activity
GO:0015094 lead ion transmembrane transporter activity
GO:0015099 nickel cation transmembrane transporter activity
GO:0015100 vanadium ion transmembrane transporter activity
GO:0015295 solute:proton symporter activity
GO:0016151 nickel cation binding
GO:0022890 inorganic cation transmembrane transporter activity
GO:0030145 manganese ion binding
GO:0046870 cadmium ion binding
GO:0050897 cobalt ion binding
Biological Process
GO:0000041 transition metal ion transport
GO:0001666 response to hypoxia
GO:0003032 detection of oxygen
GO:0006778 porphyrin-containing compound metabolic process
GO:0006779 porphyrin-containing compound biosynthetic process
GO:0006783 heme biosynthetic process
GO:0006810 transport
GO:0006824 cobalt ion transport
GO:0006825 copper ion transport
GO:0006826 iron ion transport
GO:0006828 manganese ion transport
GO:0006878 cellular copper ion homeostasis
GO:0006879 cellular iron ion homeostasis
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process
GO:0007611 learning or memory
GO:0010039 response to iron ion
GO:0010042 response to manganese ion
GO:0010288 response to lead ion
GO:0015675 nickel cation transport
GO:0015676 vanadium ion transport
GO:0015684 ferrous iron transport
GO:0015692 lead ion transport
GO:0015992 proton transport
GO:0034599 cellular response to oxidative stress
GO:0035444 nickel cation transmembrane transport
GO:0046686 response to cadmium ion
GO:0048813 dendrite morphogenesis
GO:0048821 erythrocyte development
GO:0055085 transmembrane transport
GO:0060586 multicellular organismal iron ion homeostasis
GO:0070574 cadmium ion transmembrane transport
GO:0070627 ferrous iron import
GO:0071281 cellular response to iron ion
GO:0071356 cellular response to tumor necrosis factor
GO:0071421 manganese ion transmembrane transport
GO:0071456 cellular response to hypoxia
GO:0071577 zinc ion transmembrane transport
GO:1902600 hydrogen ion transmembrane transport
GO:1902861 copper ion import into cell
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005764 lysosome
GO:0005765 lysosomal membrane
GO:0005768 endosome
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005773 vacuole
GO:0005802 trans-Golgi network
GO:0005886 plasma membrane
GO:0005887 integral component of plasma membrane
GO:0005903 brush border
GO:0009986 cell surface
GO:0012505 endomembrane system
GO:0016020 membrane
GO:0016021 integral component of membrane
GO:0016324 apical plasma membrane
GO:0031410 cytoplasmic vesicle
GO:0031902 late endosome membrane
GO:0045177 apical part of cell
GO:0045178 basal part of cell
GO:0048471 perinuclear region of cytoplasm
GO:0055037 recycling endosome
GO:0070826 paraferritin complex
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000023030
View Gene Order
ENSBTAG00000032914
Not yet available
Pathways
NETPATH
REACTOME
REACT_25060
Iron uptake and transport pathway
REACT_20547
Metal ion SLC transporters pathway
REACT_19305
Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds pathway
REACT_15518
Transmembrane transport of small molecules pathway
REACT_19118
SLC-mediated transmembrane transport pathway
KEGG
hsa04142
Lysosome pathway
INOH
PID NCI
hif2pathway
HIF-2-alpha transcription factor network
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene 4891
UniGene Hs.505545 Hs.743108
RefSeq NM_000617 NM_001174125 NM_001174126 NM_001174127 NM_001174128 NM_001174129 NM_001174130 XM_005268911 XM_005268912 XM_005268913 XM_005268914 XM_005268916
HUGO HGNC:10908
OMIM 600523
CCDS CCDS53791 CCDS53792 CCDS53793 CCDS8805
HPRD 02750
IMGT
EMBL
GenPept
RNA Seq Atlas 4891

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca