Version 5.4
Homo sapiens Gene: RAI1
Summary
InnateDB Gene IDBG-33130.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol RAI1
Gene Name retinoic acid induced 1
Synonyms SMCR; SMS
Species Homo sapiens
Ensembl Gene ENSG00000108557
Encoded Proteins
IDBP-33132
retinoic acid induced 1
IDBP-238869
retinoic acid induced 1
IDBP-760230
IDBP-759124
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene is located within the Smith-Magenis syndrome region on chromosome 17. It is highly similar to its mouse counterpart and is expressed at high levels mainly in neuronal tissues. The protein encoded by this gene includes a polymorphic polyglutamine tract in the N-terminal domain. Expression of the mouse counterpart in neurons is induced by retinoic acid. This gene is associated with both the severity of the phenotype and the response to medication in schizophrenic patients. [provided by RefSeq, Jul 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 17:17681473-17811453
Strand Forward strand
Band p11.2
Transcripts
ENST00000353383 ENSP00000323074
ENST00000395774 ENSP00000379120
ENST00000489697
ENST00000471135 ENSP00000463607
ENST00000583166 ENSP00000463984
ENST00000582514
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 28 experimentally validated interaction(s) in this database.
Experimentally validated
Total 28 [view]
Protein-Protein 26 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 2 [view]
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0008270 zinc ion binding
GO:0035326 enhancer binding
Biological Process
GO:0001501 skeletal system development
GO:0006357 regulation of transcription from RNA polymerase II promoter
GO:0032922 circadian regulation of gene expression
GO:0040015 negative regulation of multicellular organism growth
GO:0045893 positive regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000062115
View Gene Order
ENSBTAG00000004768
Not yet available
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.655395 Hs.737416
RefSeq NM_030665
HUGO
OMIM
CCDS CCDS11188
HPRD 07406
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca