Version 5.4
Homo sapiens Gene: EIF3H
Summary
InnateDB Gene IDBG-33353.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EIF3H
Gene Name eukaryotic translation initiation factor 3, subunit H
Synonyms eIF3-gamma; eIF3-p40; EIF3S3
Species Homo sapiens
Ensembl Gene ENSG00000147677
Encoded Proteins
IDBP-33355
eukaryotic translation initiation factor 3, subunit H
IDBP-479840
eukaryotic translation initiation factor 3, subunit H
IDBP-473695
eukaryotic translation initiation factor 3, subunit H
IDBP-479882
eukaryotic translation initiation factor 3, subunit H
IDBP-477943
eukaryotic translation initiation factor 3, subunit H
IDBP-484116
eukaryotic translation initiation factor 3, subunit H
IDBP-482294
eukaryotic translation initiation factor 3, subunit H
IDBP-477688
eukaryotic translation initiation factor 3, subunit H
IDBP-809877
eukaryotic translation initiation factor 3, subunit H
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Currently no Entrez Summary Available. You might want to check the Summary Sections of the Orthologs.
Gene Information
Type Protein coding
Genomic Location Chromosome 8:116642130-116766925
Strand Reverse strand
Band q24.11
Transcripts
ENST00000276682 ENSP00000276682
ENST00000521861 ENSP00000429931
ENST00000520289
ENST00000518949 ENSP00000428195
ENST00000518995 ENSP00000428669
ENST00000522800 ENSP00000429884
ENST00000518034
ENST00000517974
ENST00000522453 ENSP00000428885
ENST00000519046 ENSP00000430926
ENST00000520813 ENSP00000427908
ENST00000611080 ENSP00000482724
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 89 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 89 [view]
Protein-Protein 89 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003743 translation initiation factor activity
GO:0005515 protein binding
GO:0044822 poly(A) RNA binding
Biological Process
GO:0001731 formation of translation preinitiation complex
GO:0006412 translation
GO:0006413 translational initiation
GO:0006446 regulation of translational initiation
GO:0010467 gene expression
GO:0044267 cellular protein metabolic process
Cellular Component
GO:0005829 cytosol
GO:0005852 eukaryotic translation initiation factor 3 complex
GO:0016020 membrane
GO:0016282 eukaryotic 43S preinitiation complex
GO:0033290 eukaryotic 48S preinitiation complex
GO:0070062 extracellular vesicular exosome
GO:0071541 eukaryotic translation initiation factor 3 complex, eIF3m
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000022312
View Gene Order
ENSBTAG00000014032
Not yet available
Pathways
NETPATH
REACTOME
REACT_79
L13a-mediated translational silencing of Ceruloplasmin expression pathway
REACT_2085
GTP hydrolysis and joining of the 60S ribosomal subunit pathway
REACT_1979
Translation initiation complex formation pathway
REACT_1258
Activation of the mRNA upon binding of the cap-binding complex and eIFs, and subsequent binding to 43S pathway
REACT_1797
Formation of a pool of free 40S subunits pathway
REACT_1079
Formation of the ternary complex, and subsequently, the 43S complex pathway
REACT_931
Ribosomal scanning and start codon recognition pathway
REACT_2159
Eukaryotic Translation Initiation pathway
REACT_1014
Translation pathway
REACT_17015
Metabolism of proteins pathway
REACT_2099
Cap-dependent Translation Initiation pathway
REACT_71
Gene Expression pathway
KEGG
hsa03013
RNA transport pathway
INOH
PID NCI
Cross-References
SwissProt
TrEMBL
UniProt Splice Variant
Entrez Gene
UniGene Hs.23606 Hs.492599 Hs.694542 Hs.706085 Hs.739650
RefSeq NM_003756
HUGO
OMIM
CCDS CCDS6319
HPRD 04885
IMGT
EMBL
GenPept
RNA Seq Atlas

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca