Version 5.4
Homo sapiens Gene: ARSK
Summary
InnateDB Gene IDBG-33726.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARSK
Gene Name arylsulfatase family, member K
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000164291
Encoded Proteins
IDBP-33728
arylsulfatase family, member K
IDBP-482127
arylsulfatase family, member K
IDBP-481134
arylsulfatase family, member K
IDBP-478385
arylsulfatase family, member K
IDBP-473585
arylsulfatase family, member K
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary Sulfatases (EC 3.1.5.6), such as ARSK, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008]
Gene Information
Type Protein coding
Genomic Location Chromosome 5:95555074-95605064
Strand Forward strand
Band q15
Transcripts
ENST00000380009 ENSP00000369346
ENST00000513814 ENSP00000422608
ENST00000504763 ENSP00000422126
ENST00000504873 ENSP00000423636
ENST00000512106 ENSP00000424018
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
Gene Ontology

Molecular Function
Accession GO Term
GO:0003824 catalytic activity
GO:0004065 arylsulfatase activity
GO:0008484 sulfuric ester hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0006665 sphingolipid metabolic process
GO:0006687 glycosphingolipid metabolic process
GO:0008152 metabolic process
GO:0043687 post-translational protein modification
GO:0044267 cellular protein metabolic process
GO:0044281 small molecule metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005788 endoplasmic reticulum lumen
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000021592
View Gene Order
ENSBTAG00000020178
Not yet available
Pathways
NETPATH
REACTOME
REACT_121036
The activation of arylsulfatases pathway
REACT_116105
Glycosphingolipid metabolism pathway
REACT_19323
Sphingolipid metabolism pathway
REACT_22258
Metabolism of lipids and lipoproteins pathway
REACT_22161
Post-translational protein modification pathway
REACT_1069
PTM: gamma carboxylation, hypusine formation and arylsulfatase activation pathway
REACT_17015
Metabolism of proteins pathway
REACT_111217
Metabolism pathway
KEGG
INOH
PID NCI
Cross-References
SwissProt Q6UWY0
TrEMBL
UniProt Splice Variant
Entrez Gene 153642
UniGene Hs.585051
RefSeq NM_198150
HUGO HGNC:25239
OMIM 610011
CCDS CCDS4073
HPRD 13183
IMGT
EMBL AK303855 AL832711 AY358596 AY875939 BC036047 BC130329
GenPept AAH36047 AAI30330 AAQ88959 AAW66667 BAG64796 CAD38634
RNA Seq Atlas 153642

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca