Version 5.4
Homo sapiens Gene: ARMC10
Summary
InnateDB Gene IDBG-34112.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol ARMC10
Gene Name armadillo repeat containing 10
Synonyms
Species Homo sapiens
Ensembl Gene ENSG00000170632
Encoded Proteins
IDBP-34114
armadillo repeat containing 10
IDBP-34116
armadillo repeat containing 10
IDBP-34118
armadillo repeat containing 10
IDBP-384480
armadillo repeat containing 10
IDBP-384482
armadillo repeat containing 10
IDBP-384483
armadillo repeat containing 10
IDBP-384484
armadillo repeat containing 10
IDBP-384485
armadillo repeat containing 10
IDBP-384486
armadillo repeat containing 10
IDBP-586281
armadillo repeat containing 10
Protein Structure
Useful resources Stemformatics EHFPI ImmGen
Entrez Gene
Summary This gene encodes a protein that contains an armadillo repeat and transmembrane domain. The encoded protein decreases the transcriptional activity of the tumor suppressor protein p53 through direct interaction with the DNA-binding domain of p53, and may play a role in cell growth and survival. Upregulation of this gene may play a role in hepatocellular carcinoma. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 3. [provided by RefSeq, Sep 2011]
Gene Information
Type Protein coding
Genomic Location Chromosome 7:103074881-103099764
Strand Forward strand
Band q22.1
Transcripts
ENST00000323735 ENSP00000319798
ENST00000323716 ENSP00000319412
ENST00000306450 ENSP00000305395
ENST00000454559 ENSP00000405612
ENST00000441711 ENSP00000413619
ENST00000425331 ENSP00000397969
ENST00000428183 ENSP00000396654
ENST00000434153 ENSP00000398201
ENST00000431642 ENSP00000406840
ENST00000479145
ENST00000541300 ENSP00000440463
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
Experimentally validated
Total 2 [view]
Protein-Protein 2 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005488 binding
GO:0016820 hydrolase activity, acting on acid anhydrides, catalyzing transmembrane movement of substances
Biological Process
GO:0015991 ATP hydrolysis coupled proton transport
GO:0040008 regulation of growth
Cellular Component
GO:0000221 vacuolar proton-transporting V-type ATPase, V1 domain
GO:0005739 mitochondrion
GO:0005789 endoplasmic reticulum membrane
GO:0016021 integral component of membrane
Orthologs
Species
Mus musculus
Bos taurus
Gene ID
Gene Order
ENSMUSG00000038525
View Gene Order
ENSBTAG00000014161
Not yet available
Cross-References
SwissProt
TrEMBL C9J5N7
UniProt Splice Variant
Entrez Gene 83787
UniGene Hs.287412 Hs.380752 Hs.729488 Hs.729929
RefSeq NM_001161009 NM_001161010 NM_001161011 NM_001161012 NM_001161013 NM_031905
HUGO HGNC:21706
OMIM 611864
CCDS CCDS55145 CCDS55146 CCDS55147 CCDS55148 CCDS55149 CCDS5728
HPRD 18133
IMGT
EMBL AC007683 AC073127 AC108167
GenPept
RNA Seq Atlas 83787

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca